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A Multiscale Model of Venous Thrombus Formation with Surface-Mediated Control of Blood Coagulation Cascade
Zhiliang Xu ,
Joshua Lioi ,
Jian Mu ,
Malgorzata M. Kamocka ,
Xiaomin Liu ,
Danny Z. Chen ,
Elliot D. Rosen ,
Mark Alber
May 2010
May 2010
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Abstract
A combination of the extended multiscale model, new image processing algorithms, and
biological experiments is used for studying the role of Factor VII (FVII) in venous
thrombus formation. A detailed submodel of the tissue factor pathway of blood coagulation
is introduced within the framework of the multiscale model to provide a detailed description
of coagulation cascade. Surface reactions of the extrinsic coagulation pathway on
membranes of platelets are studied under different flow conditions. It is shown that
low levels of FVII in blood result in a significant delay in thrombin production,
demonstrating that FVII plays an active role in promoting thrombus development at
an early stage.
Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.