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      miR-137: A Novel Therapeutic Target for Human Glioma

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          Abstract

          MicroRNA (miR)-137 is highly expressed in the brain and plays a crucial role in the development and prognosis of glioma. In this review, we aim to summarize the latest findings regarding miR-137 in glioma cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. In addition, we focus on the identified miR-137 targets and pathways in the occurrence and development of glioma. Finally, future implications for the diagnostic and therapeutic potential of miR-137 in glioma were discussed.

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          Abstract

          miR-137 is highly expressed in the brain and plays a crucial role in the development and prognosis of glioma. In this review, Ma and colleagues summarize the latest findings regarding miR-137 in glioma cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and in cancer treatment.

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          Most cited references117

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          MicroRNAs: genomics, biogenesis, mechanism, and function.

          MicroRNAs (miRNAs) are endogenous approximately 22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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            MicroRNAs

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              Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.

              To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be developed. Here we show that exosomes-endogenous nano-vesicles that transport RNAs and proteins-can deliver short interfering (si)RNA to the brain in mice. To reduce immunogenicity, we used self-derived dendritic cells for exosome production. Targeting was achieved by engineering the dendritic cells to express Lamp2b, an exosomal membrane protein, fused to the neuron-specific RVG peptide. Purified exosomes were loaded with exogenous siRNA by electroporation. Intravenously injected RVG-targeted exosomes delivered GAPDH siRNA specifically to neurons, microglia, oligodendrocytes in the brain, resulting in a specific gene knockdown. Pre-exposure to RVG exosomes did not attenuate knockdown, and non-specific uptake in other tissues was not observed. The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice.
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                Author and article information

                Contributors
                Journal
                Mol Ther Nucleic Acids
                Mol Ther Nucleic Acids
                Molecular Therapy. Nucleic Acids
                American Society of Gene & Cell Therapy
                2162-2531
                30 June 2020
                04 September 2020
                30 June 2020
                : 21
                : 614-622
                Affiliations
                [1 ]Maternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical University, Foshan 528300, China
                [2 ]Clinical Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
                [3 ]Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
                [4 ]Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
                [5 ]Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
                Author notes
                []Corresponding author: You Li, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China. dreamly2001@ 123456126.com
                [∗∗ ]Corresponding author: Guoda Ma, Maternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical University, Foshan 528300, China. sihan1107@ 123456126.com
                Article
                S2162-2531(20)30189-X
                10.1016/j.omtn.2020.06.028
                7393316
                32736290
                60cdf05d-0d69-4916-85ce-be728d1b5416
                © 2020 The Author(s)

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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                Categories
                Article

                Molecular medicine
                glioma,mir-137,target genes,diagnosis,treatment
                Molecular medicine
                glioma, mir-137, target genes, diagnosis, treatment

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