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      NF-κB in Oxidative Stress

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      Current opinion in toxicology

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          Abstract

          The transcription factor nuclear factor-κB (NF-κB) modulates gene expression in diverse cellular processes such as innate immune response, embryogenesis and organ development, cell proliferation and apoptosis, and stress responses to a variety of noxious stimuli. When cellular production of reactive oxygen species (ROS) overwhelms its antioxidant capacity, it leads to a state of oxidative stress, which in turn contributes to the pathogenesis of several human diseases. Different models of oxidative stress have been studied to elucidate the effects of oxidant stress on NF-κB related activities. ROS can both activate and repress NF-κB signaling in a phase and context dependent manner. The NF-κB pathway can have both anti- and pro-oxidant roles in the setting of oxidative stress. In this review, we focus on role of oxidative stress on different mediators of the NF-κB pathway, and the role of NF-κB activation in the modulation of oxidative stress. A greater understanding of the complex interplay between the NF-κB signaling and oxidative stress may lead to the development of therapeutic strategies for the treatment of a myriad of human diseases for which oxidative stress has an etiologic role.

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          Author and article information

          Journal
          101697847
          46024
          Curr Opin Toxicol
          Curr Opin Toxicol
          Current opinion in toxicology
          2468-2934
          2468-2020
          14 November 2017
          7 November 2017
          February 2018
          01 February 2019
          : 7
          : 81-86
          Affiliations
          [1 ]Department of Pediatrics, Section of Neonatology, Texas Children’s Hospital, Baylor College of Medicine, Houston, Texas, USA. Address: 1102 Bates Avenue, MC: FC530.01, Houston, Texas 77030
          Author notes
          Corresponding author: Krithika Lingappan, Department of Pediatrics, Section of Neonatology, Texas Children’s Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, Texas 77030. Phone: +1-832-824-3208. Fax: +1-832-825-3204. lingappa@ 123456bcm.edu
          Article
          PMC5978768 PMC5978768 5978768 nihpa918574
          10.1016/j.cotox.2017.11.002
          5978768
          29862377
          60d29911-fd95-40f8-92b1-41259f413bfe
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