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      “Less is More” in mechanical ventilation

      brief-report
        1 , , 1 , 2
      Intensive Care Medicine
      Springer Berlin Heidelberg

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          Abstract

          Though formed in the late 1960s, the field of intensive care medicine solidified its place in the 1970s. Critical care practitioners were typically young and enthusiastic, but lacked the benefit of guidance from an established scientific literature or the experience of “older mentors,” as simply they did not exist. The rational basis of this new specialty was systems physiology and short-term observation, on which most of its monitoring and interventions are based. Interestingly, not only were the “intensivists” young, but so were the patients, compared to now. Very importantly, we naively assumed uniformity of diseases and disease mechanisms and translated our familiar deep knowledge of normal physiology to the pathologic state. Energy, enthusiasm and the pioneering attitudes of the young intensivists were associated with a widespread tendency to “exceed” the confines of prior experience. Adverse consequences gradually became evident. This exuberance characterized many elements of practice: in septic patients, if milligrams of corticosteroids are good, grams might be better [1]. In nutrition, if 2000 kcal/day is good, 5000 must be better [2]. The same applies to sedations and fluids administration. In hemodynamics, supra-normal values of oxygen transport must be better [3], etc. Essentially, the intensivists of that era were doing the same things as we are now, but with far greater dosage, extent and intensity. ARDS is one of the best examples of our evolution from “more-to-less,” nurtured by the difficult lessons of our experience (Fig. 1). Fig. 1 Examples of habit changes throughout the decades of the intensive care intervention (C.I.: Cardiac Index, PBW: Predicted Body Weight) Inspired Oxygen Fraction (FiO2) In the 1970s, when ARDS became the signature challenge of intensive care, the assumed goal was improved O2 delivery and a key risk was considered pulmonary O2 toxicity. Sixty percent FiO2 demarcated the threshold to the danger zone. Accordingly, the first ECMO trial [4] was designed to decrease the risk of high FiO2 while maintaining O2 delivery, regardless of tidal volume and pressures. In subsequent years, when the dominating roles of high tidal volumes and pressures in causing lung damage were recognized, FiO2 receded to the background, largely because of diverted interest. Only three decades later were the potential risks of sustaining high FiO2 re-evaluated [5]. Tidal Volume (TV) In the 1970s, tidal volumes of 12–15 ml/kg of observed body weight were recommended by the most prestigious groups treating ARDS [6]. This approach stemmed primarily from the assumed need to maintain normal PaCO2 and the observation that higher tidal volumes often produced less atelectasis and better arterial oxygenation in ARDS [7], as already known in the anesthesia practice at that time. It was rather quickly realized, however, that higher pressures and volumes were accompanied by a worrisome incidence of barotrauma [8]. In the late 1970s, we proposed to provide lung rest in severe ARDS by extracorporeal removal of CO2 [9]. Gentler lung ventilation for ARDS was advocated for the clinical setting by Hickling [10], who, following the experience of Perret with severe asthmatics [11], proposed reducing the intensity of conventional mechanical ventilation by allowing PaCO2 to rise. The superiority of gentler lung ventilation in observational and laboratory studies was confirmed a decade later by results from the ARMA trial of the ARDS network (6 vs 12 ml/kg of PBW). This unmitigated success, however, followed several inconclusive randomized studies with less rigorous separation of cohorts and narrower differences between them in the strength of the tested VT variable [12]. This sequence exemplifies the oft-repeated pattern of theory, anatomic knowledge, experiment, and experience leading the way toward down-regulated therapeutic dosing—not dichotomous RCTs conducted in a broadly defined population sample. Though now widely accepted by the intensive care community, even 6 ml/kg has been reported to be potentially dangerous in a subgroup of severe ARDS patients [13], leading to the current concept of “hyper-protective” ventilation [14]. In some settings, exuberant embracing of ECMO is a reflection of the impetus to “protect the lungs”—“less ventilation is more.” In so doing we now risk yielding to the same simplistic logic of the early 1970s, just with the opposite sign: if less is good, lesser must be better. Unfortunately, extremely low ventilation may be associated with several undesired effects [15]. Positive End Expiratory Pressure (PEEP) Given the positive effect of PEEP on oxygenation, using high levels of PEEP (even “super PEEP” up to 25 cm H2O) was proposed early on [16]. The importance of the chest wall properties and body position was seldom considered at that time. The price paid to apply high level of PEEP to maintain “acceptable” arterial oxygenation and O2 delivery was not immediately appreciated (and still is not by some clinicians). Indeed, PEEP ranging from 6 cm H2O (prevention of volutrauma) to 15 cm H2O (prevention of “atelectrauma”) led to similar results in three large randomized trials, suggesting that the competing risks of volutrauma and atelectrauma are offsetting across this range of PEEP in an unselected ARDS population [17]. However, at the higher levels of PEEP set after a recruitment maneuver, the risks of volutrauma and hemodynamic compromise appear to exceed the risk of atelectrauma. Indeed, the higher PEEP treatment group experienced significantly higher mortality than did the control [18]. Respiratory rate Of itself, using higher respiratory frequency has not traditionally been considered a problem, and it is set to maintain the PaCO2 within certain limits. However, caution is advised, especially at high levels of strain and power; in the 1970s, after some preliminary experimental reports, great enthusiasm was generated concerning high-frequency jet ventilation [19] soon abandoned, due to lack of improvement. Two decades later, however, HFOV at mean airway pressures sufficient to provide a lung volume close to total lung capacity was suggested as an ideal form of “open lung” protection (tidal volume of few ml). Results from clinical trials, however, proved discouraging [20]. We believe that the role of respiratory rate in generating VILI merits careful reevaluation, as it is an essential determinant of the mechanical power delivered to the lung [21]. Conclusion “Less is More” is a theme that characterizes the evolution and painful lessons of intensive care practice. Yet, aggressive interventions are often well justified in the stabilization phase, and it is extremely unlikely that “Lesser is invariably more than Less.”

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          Most cited references23

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          Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network.

          Traditional approaches to mechanical ventilation use tidal volumes of 10 to 15 ml per kilogram of body weight and may cause stretch-induced lung injury in patients with acute lung injury and the acute respiratory distress syndrome. We therefore conducted a trial to determine whether ventilation with lower tidal volumes would improve the clinical outcomes in these patients. Patients with acute lung injury and the acute respiratory distress syndrome were enrolled in a multicenter, randomized trial. The trial compared traditional ventilation treatment, which involved an initial tidal volume of 12 ml per kilogram of predicted body weight and an airway pressure measured after a 0.5-second pause at the end of inspiration (plateau pressure) of 50 cm of water or less, with ventilation with a lower tidal volume, which involved an initial tidal volume of 6 ml per kilogram of predicted body weight and a plateau pressure of 30 cm of water or less. The primary outcomes were death before a patient was discharged home and was breathing without assistance and the number of days without ventilator use from day 1 to day 28. The trial was stopped after the enrollment of 861 patients because mortality was lower in the group treated with lower tidal volumes than in the group treated with traditional tidal volumes (31.0 percent vs. 39.8 percent, P=0.007), and the number of days without ventilator use during the first 28 days after randomization was greater in this group (mean [+/-SD], 12+/-11 vs. 10+/-11; P=0.007). The mean tidal volumes on days 1 to 3 were 6.2+/-0.8 and 11.8+/-0.8 ml per kilogram of predicted body weight (P<0.001), respectively, and the mean plateau pressures were 25+/-6 and 33+/-8 cm of water (P<0.001), respectively. In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.
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            Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

            The effects of recruitment maneuvers and positive end-expiratory pressure (PEEP) titration on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remain uncertain.
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              Ventilator-related causes of lung injury: the mechanical power.

              We hypothesized that the ventilator-related causes of lung injury may be unified in a single variable: the mechanical power. We assessed whether the mechanical power measured by the pressure-volume loops can be computed from its components: tidal volume (TV)/driving pressure (∆P aw), flow, positive end-expiratory pressure (PEEP), and respiratory rate (RR). If so, the relative contributions of each variable to the mechanical power can be estimated.
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                Author and article information

                Contributors
                gattinoniluciano@gmail.com
                Journal
                Intensive Care Med
                Intensive Care Med
                Intensive Care Medicine
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                0342-4642
                1432-1238
                11 March 2020
                11 March 2020
                2020
                : 46
                : 4
                : 780-782
                Affiliations
                [1 ]GRID grid.7450.6, ISNI 0000 0001 2364 4210, Department of Anaesthesiology, Emergency and Intensive Care Medicine, , University of Göttingen, ; Göttingen, Germany
                [2 ]GRID grid.17635.36, ISNI 0000000419368657, University of Minnesota and Regions Hospital, ; Minneapolis/St. Paul, MN USA
                Author information
                http://orcid.org/0000-0001-5380-2494
                Article
                5981
                10.1007/s00134-020-05981-z
                7103002
                32162029
                60d3c055-e6a6-4747-bf30-3d82b9b04c38
                © The Author(s) 2020

                Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

                History
                : 31 January 2020
                : 20 February 2020
                Categories
                Less is more in Intensive Care
                Custom metadata
                © Springer-Verlag GmbH Germany, part of Springer Nature 2020

                Emergency medicine & Trauma
                Emergency medicine & Trauma

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