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      Neuroendocrine, Sympathetic and Metabolic Responses Induced by Interleukin-1

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          Abstract

          Effects on turnover of vasopressin (AVP) in the hypothalamus and on secretion of pituitary hormones, catecholamines and insulin after intraperitoneal injection of recombinant interleukin-1 (beta) (IL-1) were investigated in male wistar rats. Intraper-itoneal administration of IL-1 in a dose (1 µg) that maximally activated pituitary-adrenal activity failed to alter plasma concentrations of prolactin, luteinizing hormone and melanocyte-stimulating hormone. Rats chronically cannulated in the right jugular veins showed a time-related increase in plasma corticosterone concentrations in response to intraperitoneal administration of IL-1 that lasted up to 4 h. In the same rats, plasma epinephrine (E) and norepinephrine (NE) concentrations were only slightly elevated (2-fold increase) at 30 min and at 1 h after IL-1 administration. Unlike in endotoxin-resistant C3H/HeJ mice, where IL-1 induces hypoglycemia, IL-1 did not affect plasma concentrations of glucose and insulin in Wistar rats. In the zona externa of the median eminence, IL-1 stimulated corticotropin-releasing factor (CRF) turnover at an approximate rate of 15%/h, but did not cause a concomitant change in AVP turnover as can be observed after insulin-induced hypoglycemia. Since half of the hypothalamic CRF neurons have been shown to costore AVP, the data favor the view of a selective effect of IL-1 on a subtype of CRF neurons. We conclude that pituitary-adrenal activation in response to II-1 is caused by CRF secretion from a subtype of CRF neurons (not storing AVP) in the rat hypothalamus. Furthermore, the small and transient increase of plasma E and NE may be caused by a presynaptic action of IL-1 on sympathetic nerves in immune and/or other organs or may involve central CRF projections regulating sympathetic outflow.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1989
          1989
          02 April 2008
          : 50
          : 5
          : 570-576
          Affiliations
          aDepartment of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands; bSection of Neurobiology, Research Department, University Cantonal Hospital, Basel, Switzerland
          Article
          125283 Neuroendocrinology 1989;50:570–576
          10.1159/000125283
          2558326
          © 1989 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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