103
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The protective role of melanin against UV damage in human skin.

      1 ,
      Photochemistry and photobiology
      Wiley

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Human skin is repeatedly exposed to UVR that influences the function and survival of many cell types and is regarded as the main causative factor in the induction of skin cancer. It has been traditionally believed that skin pigmentation is the most important photoprotective factor, as melanin, besides functioning as a broadband UV absorbent, has antioxidant and radical scavenging properties. Besides, many epidemiological studies have shown a lower incidence for skin cancer in individuals with darker skin compared to those with fair skin. Skin pigmentation is of great cultural and cosmetic importance, yet the role of melanin in photoprotection is still controversial. This article outlines the major acute and chronic effects of UVR on human skin, the properties of melanin, the regulation of pigmentation and its effect on skin cancer prevention.

          Related collections

          Author and article information

          Journal
          Photochem Photobiol
          Photochemistry and photobiology
          Wiley
          0031-8655
          0031-8655
          2008
          : 84
          : 3
          Affiliations
          [1 ] Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
          Article
          NIHMS103064 PHP226
          10.1111/j.1751-1097.2007.00226.x
          2671032
          18435612
          60dc5129-9735-4bf8-a491-2d6d556b1b0c
          History

          Comments

          Comment on this article