- Record: found
- Abstract: not found
- Article: not found
Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation
Christopher D Buckley ,
Darrell Pilling ,
Janet M Lord ,
Arne N Akbar ,
Dagmar Scheel-Toellner ,
Mike Salmon
April 2001
April 2001
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Fibroblasts are important sentinel cells in the immune system and, here, it is proposed
that these cells play a critical role in the switch from acute inflammation to adaptive
immunity and tissue repair. It is suggested that chronic inflammation occurs because
of disordered fibroblast behaviour in which failure to switch off their inflammatory
programme leads to the inappropriate survival and retention of leukocytes within inflamed
tissue.