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      • Record: found
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      Pathogenetic mechanism of oral granulomatous diseases: An update

      review-article
      Author(s): 1
      Publication date (Electronic):
      Journal: Journal of Family Medicine and Primary Care
      Publisher: Wolters Kluwer - Medknow
      Keywords: Chronic, granuloma, oral, pathogenesis

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          Abstract

          Oral granulomatous diseases are an intriguing group of lesions characterized by granuloma formation. Mechanisms of granuloma formation differ from disease-to-disease. This article provides an insight into common granulomatous pathogenic mechanisms involving these lesions including immunodeficient states. Understanding various pathogenic mechanisms underlying various granulomatous conditions affecting oral tissues which mainly revolve around inflammatory cells such as macrophages, T lymphocytes, and genetic mutations might aid in devising treatment modalities without having significant side-effects or morbidity in affected subjects.

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          Most cited references24

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          Practice parameter for the diagnosis and management of primary immunodeficiency.

          Francisco Bonilla, David Khan, Zuhair K Ballas … (2015)
          The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for establishing the "Practice parameter for the diagnosis and management of primary immunodeficiency." This is a complete and comprehensive document at the current time. The medical environment is a changing environment, and not all recommendations will be appropriate for all patients. Because this document incorporated the efforts of many participants, no single individual, including those who served on the Joint Task Force, is authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters. Any request for information about or an interpretation of these practice parameters by the AAAAI or ACAAI should be directed to the Executive Offices of the AAAAI, the ACAAI, and the Joint Council of Allergy, Asthma & Immunology. These parameters are not designed for use by pharmaceutical companies in drug promotion.
          Article 0 comments Cited 197 times – based on 0 reviews     Review now
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            Chronic granulomatous disease as a risk factor for autoimmune disease.

            John Gallin, J Balow, Harry L. Malech … (2008)
            Chronic granulomatous disease (CGD) is characterized by recurrent infections and granuloma formation. In addition, we have observed a number of diverse autoimmune conditions in our CGD population, suggesting that patients with CGD are at an elevated risk for development of autoimmune disorders. In this report, we describe antiphospholipid syndrome, recurrent pericardial effusion, juvenile idiopathic arthritis, IgA nephropathy, cutaneous lupus erythematosus, and autoimmune pulmonary disease in the setting of CGD. The presence and type of autoimmune disease have important treatment implications for patients with CGD.
            Article 0 comments Cited 56 times – based on 0 reviews     Review now
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              Chronic granulomatous disease: a review of the infectious and inflammatory complications

              Eunkyung Song, Gayatri Jaishankar, Hana Saleh … (2011)
              Chronic Granulomatous Disease is the most commonly encountered immunodeficiency involving the phagocyte, and is characterized by repeated infections with bacterial and fungal pathogens, as well as the formation of granulomas in tissue. The disease is the result of a disorder of the NADPH oxidase system, culminating in an inability of the phagocyte to generate superoxide, leading to the defective killing of pathogenic organisms. This can lead to infections with Staphylococcus aureus, Psedomonas species, Nocardia species, and fungi (such as Aspergillus species and Candida albicans). Involvement of vital or large organs can contribute to morbidity and/or mortality in the affected patients. Major advances have occurred in the diagnosis and treatment of this disease, with the potential for gene therapy or stem cell transplantation looming on the horizon.
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Family Med Prim Care
                Journal ID (iso-abbrev): J Family Med Prim Care
                Journal ID (publisher-id): JFMPC
                Title: Journal of Family Medicine and Primary Care
                Publisher: Wolters Kluwer - Medknow (India )
                ISSN (Print): 2249-4863
                ISSN (Electronic): 2278-7135
                Publication date Collection: March 2020
                Publication date (Electronic): 26 March 2020
                Volume: 9
                Issue: 3
                Pages: 1283-1286
                Affiliations
                [1 ] Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, Riyadh Elm University, Riyadh, Kingdom of Saudi Arabia
                Author notes
                Address for correspondence: Dr. Nishath Sayed Abdul, Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, Riyadh Elm University, Riyadh, Kingdom of Saudi Arabia. E-mail: drnishathabdul@ 123456gmail.com
                Article
                Publisher ID: JFMPC-9-1283
                DOI: 10.4103/jfmpc.jfmpc_1162_19
                PMC ID: 7266191
                SO-VID: 60e6f0be-4757-4457-abf6-53a01e74c418
                Copyright © Copyright: © 2020 Journal of Family Medicine and Primary Care
                License:

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

                History
                Date received : 16 December 2019
                Date revision received : 31 January 2020
                Date accepted : 24 February 2020
                Categories
                Subject: Review Article

                Keywords: chronic,granuloma,oral,pathogenesis
                Data availability:
                Keywords: chronic, granuloma, oral, pathogenesis

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