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      Lack of Association between NYD-SP18 Variant and Obesity. The Health Alcohol and Psychosocial Factors in Eastern Europe Study

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          Abstract

          Aim

          To replicate the finding that the polymorphism rs6971091 within the NYD-SP18 gene is associated with body mass index (BMI).

          Method

          We analysed data of 29,284 adults (46.2% of males, mean age 58.9 (SD 7.3), mean BMI 28.6 (5.0 kg/m 2)) examined within the Health Alcohol and Psychosocial Factors in Eastern Europe study in the Czech Republic, Poland, Lithuania and Russia.

          Results

          BMI did not differ by rs6971091 genotype. In men, the mean BMI (SEs) in GG, GA and AA carriers were 27.8 (0.05), 27.9 (0.06) and 27.9 (0.14) kg/m 2, respectively, (p = 0.26); in women, the corresponding values were 29.2 (0.06), 29.1 (0.07) and 29.1 (0.16), p = 0.57. In Czech subjects (n = 6,752), for whom the FTO rs17817449 genotype was available, there was no interaction between the NYD-SP18 and FTO polymorphisms in determination of BMI. Adjustment for age, energy and fat intake and physical activity did not materially change the results. There was no association of the NYD-SP18 genotype with waist-hip ratio.

          Conclusion

          This study in a large Slavonic population sample suggests that the rs6971091 variant within the NYD-SP18 gene is not an important determinant of obesity in middle-aged persons.

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          Most cited references26

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          Reproducibility and validity of a semiquantitative food frequency questionnaire.

          WALTER WILLETT, LAURA SAMPSON, MEIR STAMPFER … (1985)
          The aim of this study was to evaluate the reproducibility and validity of a 61-item semiquantitative food frequency questionnaire used in a large prospective study among women. This form was administered twice to 173 participants at an interval of approximately one year (1980-1981), and four one-week diet records for each subject were collected during that period. Intraclass correlation coefficients for nutrient intakes estimated by the one-week diet records (range = 0.41 for total vitamin A without supplements to 0.79 for vitamin B6 with supplements) were similar to those computed from the questionnaire (range = 0.49 for total vitamin A without supplements to 0.71 for sucrose), indicating that these methods were generally comparable with respect to reproducibility. With the exception of sucrose and total carbohydrate, nutrient intakes from the diet records tended to correlate more strongly with those computed from the questionnaire after adjustment for total caloric intake. Correlation coefficients between the mean calorie-adjusted intakes from the four one-week diet records and those from the questionnaire completed after the diet records ranged from 0.36 for vitamin A without supplements to 0.75 for vitamin C with supplements. Overall, 48% of subjects in the lowest quintile of calorie-adjusted intake computed from the diet records were also in the lowest questionnaire quintile, and 74% were in the lowest one of two questionnaire quintiles. Similarly, 49% of those in the highest diet record quintile were also in the highest questionnaire quintile, and 77% were in the highest one or two questionnaire quintiles. These data indicate that a simple self-administered dietary questionnaire can provide useful information about individual nutrient intakes over a one-year period.
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            Obesity prevalence from a European perspective: a systematic review

            Anne Berghöfer, Tobias Pischon, Thomas Reinhold … (2008)
            Background Obesity has been recognised as an important contributing factor in the development of various diseases, but comparative data on this condition are limited. We therefore aimed to identify and discuss current epidemiological data on the prevalence of obesity in European countries. Methods We identified relevant published studies by means of a MEDLINE search (1990–2008) supplemented by information obtained from regulatory agencies. We only included surveys that used direct measures of weight and height and were representative of each country's overall population. Results In Europe, the prevalence of obesity (body mass index ≥ 30 kg/m2) in men ranged from 4.0% to 28.3% and in women from 6.2% to 36.5%. We observed considerable geographic variation, with prevalence rates in Central, Eastern, and Southern Europe being higher than those in Western and Northern Europe. Conclusion In Europe, obesity has reached epidemic proportions. The data presented in our review emphasise the need for effective therapeutic and preventive strategies.
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              The genetics of obesity: FTO leads the way

              Katherine A. Fawcett, Inês Barroso (2010)
              In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was identified in multiple populations, making FTO the first locus unequivocally associated with adiposity. At the time, FTO was a gene of unknown function and it was not known whether these SNPs exerted their effect on adiposity by affecting FTO or neighboring genes. Therefore, this breakthrough association inspired a wealth of in silico, in vitro, and in vivo analyses in model organisms and humans to improve knowledge of FTO function. These studies suggested that FTO plays a role in controlling feeding behavior and energy expenditure. Here, we review the approaches taken that provide a blueprint for the study of other obesity-associated genes in the hope that this strategy will result in increased understanding of the biological mechanisms underlying body weight regulation.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Ann Nutr Metab
                Journal ID (iso-abbrev): Ann. Nutr. Metab
                Journal ID (publisher-id): ANM
                Title: Annals of Nutrition & Metabolism
                Publisher: S. Karger AG (Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch )
                ISSN (Print): 0250-6807
                ISSN (Electronic): 1421-9697
                Publication date (Print): July 2016
                Publication date (Electronic): 31 May 2016
                Publication date PMC-release: 31 May 2016
                Volume: 68
                Issue: 4
                Pages: 244-248
                Affiliations
                [1] aCenter for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
                [2] bCentre for Health Monitoring, National Institute of Public Health, Prague, Czech Republic
                [3] cDepartment of Epidemiology and Public Health, University College London, London, UK
                [4] dInstitute of Internal and Preventive Medicine, Russian Academy of Medical Sciences, Novosibirsk, Russia
                [5] eDepartment of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Care, Jagiellonian University Medical College, Krakow, Poland
                [6] fDepartment of Population Studies, Institute of Cardiology of Lithuanian University of Health Sciences, Kaunas, Lithuania
                Author notes
                *Jaroslav A. Hubacek, Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, IKEM-CEM-LMG, Videnska 1958/9, CZ-14021 Prague 4 (Czech Republic), E-Mail jahb@ 123456ikem.cz
                Article
                Publisher ID: anm-0068-0244
                DOI: 10.1159/000445982
                PMC ID: 5022760
                PubMed ID: 27237450
                SO-VID: 60f5487c-b5a1-43a2-9606-39e6a1eea42c
                Copyright © Copyright © 2016 by S. Karger AG, Basel
                License:

                This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY) (http://www.karger.com/Services/OpenAccessLicense). Usage, derivative works and distribution are permitted provided that proper credit is given to the author and the original publisher.

                History
                Date received : 11 January 2016
                Date revision received : 30 March 2016
                Page count
                Tables: 2, References: 26, Pages: 5
                Categories
                Subject: Original Paper

                Keywords: nyd-sp18,polymorphism,obesity,body mass index,waist-hip ratio,fto,energy intake
                Data availability:
                Keywords: nyd-sp18, polymorphism, obesity, body mass index, waist-hip ratio, fto, energy intake

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