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      Inhibition by Methoxyverapamil of the Responses of Smooth Muscle from Spontaneously Hypertensive and Normotensive Rats

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          Abstract

          Inhibition by methoxyverapamil (D 600) of the responses to norepinephrine (NE) and KCl of vascular (carotid and iliac arteries and aortae) strips and vasa deferentia from spontaneously hypertensive (SHR) and normotensive rats (WKY) were compared. The responses of aortic and carotid arterial strips from SHR to NE and KCl were inhibited to a lesser extent by low concentrations of D 600 (≤10<sup>–6</sup> M). The isolated preparations of the iliac arteries and the vasa deferentia showed no differences in their susceptibility to inhibition by D 600. The responses to NE and KCl in calcium-free solutions of vascular strips from WKY were generally resistant to inhibition by D 600 (10<sup>–6</sup> M) in contrast to those from SHR which were markedly inhibited by D 600. Our results demonstrate that while the inhibitory action of D 600 on calcium movement may succeed in distinguishing vascular responses of SHR from those of WKY, the inhibitory pattern varies with different tissues and with experimental variations of calcium levels.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1982
          1982
          19 September 2008
          : 19
          : 4
          : 177-185
          Affiliations
          Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, N.Y., USA
          Article
          158383 Blood Vessels 1982;19:177–185
          10.1159/000158383
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Research Paper

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