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      Serum Aluminium Level in the Veneto Chronic Haemodialysis Population: Cross-Sectional Study on 1,026 Patients

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          Abstract

          A total of 1,026 patients undergoing haemodialysis as the only chronic treatment were studied in all the dialysis units of the Veneto region, Italy. Aluminium was determined in water, dialysis fluids, and patients’ serum. Aluminium mean concentration was 9.1 µg/l in tap water and 13.3 and 15.7 µg/l in bicarbonate and acetate haemodialysis fluids, respectively. Patients’ serum aluminium mean level was 52.0 µg/l with the following frequency distribution: 59.2% below 60 µg/l, 25.5% between 60 and 100 µg/l, and 15.3% above 100 µg/l. The mean serum aluminium level was higher in patients undergoing haemodialysis with aluminium concentration in fluids over 10 µg/l. This was true also in patients not receiving aluminium hydroxide. Furthermore, we found higher average serum aluminium in those treated with aluminium hydroxide more than 3 g/day. No relationship was found between serum aluminium and sex, age, dialytic age, parathyroid hormone, and vitamin D treatment. Moreover, the patients with serum aluminium above 100 µg/l had higher serum alkaline phosphatase and lower mean cell volume values. Thus, in our haemodialysis population aluminium overloading occurred in spite of low concentration in water and fluid, and it was a result more of fluid pollution (over 10 µg/l) than aluminium hydroxide ingestion (over 3 g/day).

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1989
          1989
          09 December 2008
          : 51
          : 4
          : 482-490
          Affiliations
          aInstitute of Internal Medicine, First Division of Nephrology, University of Padua; bNephrology and Dialysis Unit, ULSS 18, Dolo, Venice; cPreventional Service, Toxicology Section, ULSS 36, Mestre, Venice; dDivision of Nephrology and Dialysis, ULSS 10, Treviso, Italy
          Article
          185381 Nephron 1989;51:482–490
          10.1159/000185381
          2787000
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Original Paper

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