Root perforations that result in a communication of the root space with the periodontal tissues occasionally occur during endodontic procedures. They may be induced iatrogenically, by resorptive process, or by caries. Identification of root perforations is possible by direct observation of bleeding, indirect bleeding assessment using a paper point, radiography, and an apex locator. Prognosis of a tooth with root perforation depends on the time lapsed before obturation of the perforation, location and size of the lesion, and the sealability of the repair material. Perforation defects may be repaired by nonsurgical or surgical techniques. A review of causes, diagnosis, prognosis, and management of root perforations provides information for avoiding, detecting, and treating of such defects.