Beneficial Effects of Angiotensin-Converting Enzyme Inhibitor on Renal Function and Glucose Homeostasis in Diabetics with Hypertension

Abstract

The antihypertensive efficacy of enalapril and its effects on renal function and glucose homeostasis were investigated in 9 hypertensive patients with non-insulin-dependent diabetes mellitus. Enalapril therapy produced a significant fall in blood pressure (BP) (p < 0.05) and a significant increase in renal blood flow (p < 0.05) without a change in glomerular filtration rate. Furthermore, fasting plasma glucose was significantly reduced (p < 0.01). Similarly, M value, as an index of plasma glucose control in diabetes, was significantly reduced from 19.6 to 10.1 (p < 0.01). These findings suggested that the angiotensin-converting enzyme inhibitor enalapril was effective in reducing BP and improving renal function, and might improve glucose homeostasis in hypertensive diabetics.