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      Quantitative Changes in the Size of Fenestrations of the Elastic Laminae of Sheep Thoracic Aorta Studied with SEM


      Journal of Vascular Research

      S. Karger AG

      Sheep thoracic aorta, IEL fenestration analysis, Hot alkaline digestion

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          The elastic laminae were extracted from thoracic aortas of 6 adult sheep by treating them in 0.1 N NaOH at 75 °C, and the surface of internal elastic lamina (IEL) was observed for windows by scanning electron microscopy. The fenestration analysis on IEL showed that mean diameters of the holes ranged from 0.46 µm ( ± 0.013 SEM) to 1.35 µm ( ± 1.019 SEM), which is smaller than those of human cerebral arteries (7.0 ± 0.34 at the apex of the bifurcation and 2.1 ± 0.13 SEM µm in the straight sections; [3]), and mean densities ranged from 6,513 to 31,544/mm2. Both size and density of windows are found to increase when the digestion time in the hot alkaline solution is increased form 1 to 3 h. It is concluded that the IEL of the sheep thoracic aorta has smaller windows than human cerebral arteries and because of the wall thickness the thoracic aorta requires longer digestion times than human cerebral arteries.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 20
          : 3
          : 145-153
          Department of Biophysics, Health Science Centre, University of Western Ontario, London, Ont., Canada
          158468 Blood Vessels 1983;20:145–153
          © 1983 S. Karger AG, Basel

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          Page count
          Pages: 9
          Research Paper


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