Quantitative Changes in the Size of Fenestrations of the Elastic Laminae of Sheep Thoracic Aorta Studied with SEM

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Abstract

The elastic laminae were extracted from thoracic aortas of 6 adult sheep by treating them in 0.1 N NaOH at 75 °C, and the surface of internal elastic lamina (IEL) was observed for windows by scanning electron microscopy. The fenestration analysis on IEL showed that mean diameters of the holes ranged from 0.46 µm ( ± 0.013 SEM) to 1.35 µm ( ± 1.019 SEM), which is smaller than those of human cerebral arteries (7.0 ± 0.34 at the apex of the bifurcation and 2.1 ± 0.13 SEM µm in the straight sections; [3]), and mean densities ranged from 6,513 to 31,544/mm2. Both size and density of windows are found to increase when the digestion time in the hot alkaline solution is increased form 1 to 3 h. It is concluded that the IEL of the sheep thoracic aorta has smaller windows than human cerebral arteries and because of the wall thickness the thoracic aorta requires longer digestion times than human cerebral arteries.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1983

Publication date (Print): 1983

Publication date (Electronic): 19 September 2008

Volume: 20

Issue: 3

Pages: 145-153

Affiliations

Department of Biophysics, Health Science Centre, University of Western Ontario, London, Ont., Canada

Article

Publisher ID: 158468 Other ID: Blood Vessels 1983;20:145–153

DOI: 10.1159/000158468

SO-VID: 613d512c-2ee7-4d71-adbc-40b122ea6d3f

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 10 May 1982

Date accepted : 09 July 1982

Page count

Pages: 9

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