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Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography
August 2000
August 2000
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Abstract
A method for the simultaneous determination of losartan potassium and hydrochlorothiazide
in tablets is described. The procedure, based on the use of reversed-phase high-performance
liquid chromatography, is linear in the concentration range 3.0-7.0 microg ml(-1)
for losartan and 0.5-2.0 microg ml(-1) for hydrochlorothiazide, is simple and rapid
and allows accurate and precise results. The limit of detection was 0.08 microg ml(-1)
for losartan and 0.05 microg ml(-1) for hydrochlorothiazide.