Blog
About

  • Record: found
  • Abstract: found
  • Article: found

Letting sleeping dos lie: does dormancy play a role in tuberculosis?

Annual review of microbiology

Virulence, physiology, pathogenicity, growth & development, Mycobacterium tuberculosis, Models, Biological, microbiology, Latent Tuberculosis, Humans, Drug Resistance, Bacterial, Disease Models, Animal, pharmacology, Antitubercular Agents, Animals

Read this article at

ScienceOpenPublisherPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Mycobacterium tuberculosis, which causes tuberculosis, remains a major human public health threat. This is largely due to a sizeable reservoir of latently infected individuals, who may relapse into active disease decades after first acquiring the infection. Furthermore, patients have a very slow response to treatment of active disease. Latency and antibiotic tolerance are commonly taken as a proxy for dormancy, a stable nonreplicative state. However, latency is a clinical term that is solely defined by a lack of disease indicators. The actual state of the bacterium in human latency is not well understood. Here we evaluate the results of several in vitro models of dormancy and consider the applicability of various animal models for studying aspects of human latency and resistance to killing by antibiotics. Furthermore, we propose a model for the initiation of dormancy and resuscitation during infection.

      Related collections

      Author and article information

      Journal
      10.1146/annurev.micro.112408.134043
      20825351

      Comments

      Comment on this article