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      Inhibition of Ovarian Follicle Growth by a Chemical Antiestrogen

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      Hormone Research in Paediatrics

      S. Karger AG

      Thymidine uptake, Follicle growth, FSH, Estrogen, Antiestrogen

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          Effect of a chemical antiestrogen, cis-clomiphene, on FSH-induced ovarian follicle growth was studied morphometrically in hypophysectomized immature female rats. NIH-FSH-S<sub>12</sub> alone or in combination with cis-clomiphene was injected to hypophysectomized rats and the ovarian weight, histological findings of the ovary, the number of growing and atretic follicles, the uptake of tritiated thymidine by the ovary and labelling indices of growing follicles were investigated with reference to their morphometric aspects. A chemical antiestrogen, cis-clomiphene, inhibited FSH-induced ovarian follicle growth. The results suggest that endogenous estrogen secretion plays a role in the ovarian response to FSH, and FSH-induced follicular growth is mediated by endogenous estrogen.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 16
          : 4
          : 230-236
          Department of Obstetrics and Gynecology, Wakayama Medical College, Wakayama, Japan
          179506 Horm Res 1982;16:230–236
          © 1982 S. Karger AG, Basel

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          Pages: 7


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