2
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Biomolecular basis of the role of diabetes mellitus in osteoporosis and bone fractures.

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Osteoporosis has become a serious health problem throughout the world which is associated with an increased risk of bone fractures and mortality among the people of middle to old ages. Diabetes is also a major health problem among the people of all age ranges and the sufferers due to this abnormality increasing day by day. The aim of this review is to summarize the possible mechanisms through which diabetes may induce osteoporosis. Diabetes mellitus generally exerts its effect on different parts of the body including bone cells specially the osteoblast and osteoclast, muscles, retina of the eyes, adipose tissue, endocrine system specially parathyroid hormone (PTH) and estrogen, cytokines, nervous system and digestive system. Diabetes negatively regulates osteoblast differentiation and function while positively regulates osteoclast differentiation and function through the regulation of different intermediate factors and thereby decreases bone formation while increases bone resorption. Some factors such as diabetic neuropathy, reactive oxygen species, Vitamin D, PTH have their effects on muscle cells. Diabetes decreases the muscle strength through regulating these factors in various ways and ultimately increases the risk of fall that may cause bone fractures.

          Related collections

          Author and article information

          Journal
          World J Diabetes
          World journal of diabetes
          1948-9358
          Aug 15 2013
          : 4
          : 4
          Affiliations
          [1 ] Bipradas Roy, Biotechnology and Genetic Engineering, Life Science School, Khulna University, Khulna-9208, Bangladesh.
          Article
          10.4239/wjd.v4.i4.101
          3746082
          23961320
          61b0bed4-49f6-486f-8cbb-5ee47e283591
          History

          Advanced glycation end product,Angiotensin II,Diabetes,Diabetic neuropathy,Insulin,Interleukin 6,Muscle atrophy,Osteoporosis,Receptor activator for nuclear factor κ-B ligand,Tumor necrosis factor

          Comments

          Comment on this article