Impaired kidney function is associated with lower quality of life among community-dwelling older adults : The screening for CKD among older people across Europe (SCOPE) study

Abstract

Background

Quality of life (QoL) refers to the physical, psychological, social and medical aspects of life that are influenced by health status and function. The purpose of this study was to measure the self-perceived health status among the elderly population across Europe in different stages of Chronic Kidney Disease (CKD).

Methods

Our series consisted of 2255 community-dwelling older adults enrolled in the Screening for Chronic Kidney Disease (CKD) among Older People across Europe (SCOPE) study. All patients underwent a comprehensive geriatric assessment (CGA), including included demographics, clinical and physical assessment, number of medications taken, family arrangement, Geriatric Depression Scale (GDS), Cumulative Illness Rating Scale, History of falls, Lower urinary tract symptoms, and Short Physical Performance Battery (SPPB). Estimated glomerular filtration rate (eGFR) was calculated by Berlin Initiative Study (BIS) equation. Quality of life was assessed by Euro Qol questionnaire (Euro-Qol 5D) and EQ-Visual Analogue Scale (EQ-VAS). The association between CKD (eGFR < 60, < 45 ml or < 30 ml/min/1.73m ²) and low EQoL-VAS was investigated by multivariable logistic regression models.

Results

CKD was found to be significantly associated with low EQoL-VAS in crude analysis (OR = 1.47, 95%CI = 1.16–1.85 for eGFR< 60; OR = 1.38, 95%CI = 1.08–1.77 for eGFR< 45; OR = 1.57, 95%CI = 1.01–2.44). Such association was no longer significant only when adjusting for SPPB (OR = 1.20, 95%CI = 0.93–1.56 for eGFR< 60; OR = 0.87, 95%CI = 0.64–1.18 for eGFR< 45; OR = 0.84, 95%CI = 0.50–1.42), CIRS and polypharmacy (OR = 1.16, 95%CI = 0.90–1.50 for eGFR< 60; OR = 0.86, 95%CI = 0.64–1.16 for eGFR< 45; OR = 1.11, 95%CI = 0.69–1.80) or diabetes, hypertension and chronic obstructive pulmonary disease (OR = 1.28, 95%CI = 0.99–1.64 for eGFR< 60; OR = 1.16, 95%CI = 0.88–1.52 for eGFR< 45; OR = 1.47, 95%CI = 0.92–2.34). The association between CKD and low EQoL-VAS was confirmed in all remaining multivariable models.

Conclusions

CKD may significantly affect QoL in community-dwelling older adults. Physical performance, polypharmacy, diabetes, hypertension and COPD may affect such association, which suggests that the impact of CKD on QoL is likely multifactorial and partly mediated by co-occurrent conditions/risk factors.

Contributors

Rada Artzi-Medvedik: [e-mail]

Robert Kob: [e-mail]

Paolo Fabbietti:

ORCID: http://orcid.org/0000-0003-2130-3070

[e-mail]

Fabrizia Lattanzio: [e-mail]

Andrea Corsonello: [e-mail]

Yehudit Melzer: [e-mail]

Regina Roller-Wirnsberger: [e-mail]

Gerhard Wirnsberger: [e-mail]

Francesco Mattace-Raso: [e-mail]

Lisanne Tap: [e-mail]

Pedro Gil: [e-mail]

Sara Lainez Martinez: [e-mail]

Francesc Formiga: [e-mail]

Rafael Moreno-González: [e-mail]

Tomasz Kostka: [e-mail]

Agnieszka Guligowska: [e-mail]

Johan Ärnlöv: [e-mail]

Axel C. Carlsson: [e-mail]

Ellen Freiberger: [e-mail]

Itshak Melzer: [e-mail]

Journal

Journal ID (nlm-ta): BMC Geriatr

Title: BMC Geriatrics

Publisher: BioMed Central (London )

ISSN (Electronic): 1471-2318

Publication date (Electronic): 2 October 2020

Publication date PMC-release: 2 October 2020

Publication date Collection: 2020

Volume: 20

Issue : Suppl 1 Issue sponsor : SCOPE study and publication costs are funded by the European Union Horizon 2020 program. The articles have undergone the journal's standard peer review process for supplements. The Supplement Editors declare that they have no competing interests.

Affiliations

[1 ]GRID grid.7489.2, ISNI 0000 0004 1937 0511, Department of Nursing, Recanati School for Community Health Professions at the faculty of Health Sciences, , Ben-Gurion University of the Negev, ; Beer-sheva, Israel

[2 ]GRID grid.7489.2, ISNI 0000 0004 1937 0511, Department of Physical Therapy, Recanati School for Community Health Professions at the faculty of Health Sciences, , Ben-Gurion University of the Negev, ; Beer-sheva, Israel

[3 ]GRID grid.5330.5, ISNI 0000 0001 2107 3311, Department of Internal Medicine-Geriatrics, , Institute for Biomedicine of Aging, Krankenhaus Barmherzige Brüder, Friedrich-Alexander Universität Erlangen-Nürnberg, ; Koberger Strasse 60, 90408 Nuremberg, Germany

[4 ]GRID grid.418083.6, ISNI 0000 0001 2152 7926, Italian National Research Center on Aging (IRCCS INRCA), ; Ancona, Fermo and Cosenza Italy

[5 ]Laboratory of Geriatric Pharmacoepidemiology and Biostatistics, IRCCS INRCA, Via S. Margherita 5, 60124 Ancona, Italy

[6 ]Maccabi Health Organization, Negev district, Tel Aviv-Yafo, Israel

[7 ]GRID grid.11598.34, ISNI 0000 0000 8988 2476, Department of Internal Medicine, , Medical University of Graz, ; Graz, Austria

[8 ]GRID grid.11598.34, ISNI 0000 0000 8988 2476, Division of Nephrology, Department of Internal Medicine, , Medical University of Graz, ; Graz, Austria

[9 ]GRID grid.5645.2, ISNI 000000040459992X, Department of Internal Medicine, Section of Geriatric Medicine, , Erasmus MC, University Medical Center Rotterdam, ; Rotterdam, The Netherlands

[10 ]GRID grid.411068.a, ISNI 0000 0001 0671 5785, Department of Geriatric Medicine, , Hospital Clinico San Carlos, ; Madrid, Spain

[11 ]GRID grid.411129.e, ISNI 0000 0000 8836 0780, Geriatric Unit, Internal Medicine Department, , Bellvitge University Hospital – IDIBELL – L’Hospitalet de Llobregat, ; Barcelona, Spain

[12 ]GRID grid.8267.b, ISNI 0000 0001 2165 3025, Department of Geriatrics, Healthy Ageing Research Centre, , Medical University of Lodz, ; Lodz, Poland

[13 ]GRID grid.8993.b, ISNI 0000 0004 1936 9457, Department of Medical Sciences, , Uppsala University, ; Uppsala, Sweden

[14 ]GRID grid.411953.b, ISNI 0000 0001 0304 6002, School of Health and Social Studies, , Dalarna University, ; Falun, Sweden

[15 ]GRID grid.4714.6, ISNI 0000 0004 1937 0626, Division of Family Medicine, Department of Neurobiology, Care Sciences and Society, , Karolinska Institutet, ; Huddinge, Sweden

Article

Publisher ID: 1697

DOI: 10.1186/s12877-020-01697-3

PMC ID: 7530949

Copyright statement: © The Author(s) 2020

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Funding

Funded by: FundRef http://dx.doi.org/10.13039/100010661, Horizon 2020 Framework Programme;

Award ID: 634869

Award ID: 634869

Award ID: 634869

Award ID: 634869

Award ID: 634869

Award ID: 634869

Award ID: 634869

Award ID: 634869

Award Recipient : Fabrizia Lattanzio Gerhard Wirnsberger Pedro Gil Francesc Formiga Tomasz Kostka Johan Ärnlöv Itshak Melzer

Categories

Subject: Research

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issue-copyright-statement © The Author(s) 2020