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      Optical Biosensors: A Revolution Towards Quantum Nanoscale Electronics Device Fabrication

      review-article
      1 , * , 2
      Journal of Biomedicine and Biotechnology
      Hindawi Publishing Corporation

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          Abstract

          The dimension of biomolecules is of few nanometers, so the biomolecular devices ought to be of that range so a better understanding about the performance of the electronic biomolecular devices can be obtained at nanoscale. Development of optical biomolecular device is a new move towards revolution of nano-bioelectronics. Optical biosensor is one of such nano-biomolecular devices that has a potential to pave a new dimension of research and device fabrication in the field of optical and biomedical fields. This paper is a very small report about optical biosensor and its development and importance in various fields.

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          Most cited references64

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          Nanotube molecular wires as chemical sensors

          Chemical sensors based on individual single-walled carbon nanotubes (SWNTs) are demonstrated. Upon exposure to gaseous molecules such as NO(2) or NH(3), the electrical resistance of a semiconducting SWNT is found to dramatically increase or decrease. This serves as the basis for nanotube molecular sensors. The nanotube sensors exhibit a fast response and a substantially higher sensitivity than that of existing solid-state sensors at room temperature. Sensor reversibility is achieved by slow recovery under ambient conditions or by heating to high temperatures. The interactions between molecular species and SWNTs and the mechanisms of molecular sensing with nanotube molecular wires are investigated.
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            DNA biosensors and microarrays.

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              Self-Assembled Metal Colloid Monolayers: An Approach to SERS Substrates.

              The self-assembly of monodisperse gold and silver colloid particles into monolayers on polymer-coated substrates yields macroscopic surfaces that are highly active for surface-enhanced Raman scattering (SERS). Particles are bound to the substrate through multiple bonds between the colloidal metal and functional groups on the polymer such as cyanide (CN), amine (NH(2)), and thiol (SH). Surface evolution, which can be followed in real time by ultraviolet-visible spectroscopy and SERS, can be controlled to yield high reproducibility on both the nanometer and the centimeter scales. On conducting substrates, colloid monolayers are electrochemically addressable and behave like a collection of closely spaced microelectrodes. These favorable properties and the ease of monolayer construction suggest a widespread use for metal colloid-based substrates.
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                Author and article information

                Journal
                J Biomed Biotechnol
                JBB
                Journal of Biomedicine and Biotechnology
                Hindawi Publishing Corporation
                1110-7243
                1110-7251
                2011
                29 October 2011
                : 2011
                : 348218
                Affiliations
                1Department of Engineering Physics, Tripura Institute of Technology, Narsingarh, Tripura-799009, India
                2Department of Electronics and Telecommunication, Tripura Institute of Technology, Narsingarh, Tripura-799009, India
                Author notes

                Academic Editor: Paul W. Doetsch

                Article
                10.1155/2011/348218
                3205924
                22131802
                61b7059b-867c-42f6-95de-696a81511bc9
                Copyright © 2011 D. Dey and T. Goswami.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 16 June 2011
                : 9 August 2011
                Categories
                Review Article

                Molecular medicine
                Molecular medicine

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