- Record: found
- Abstract: not found
- Article: not found
Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain
N. B. Nabulsi ,
J. Mercier ,
D. Holden ,
S. Carre ,
S. Najafzadeh ,
M.-C. Vandergeten ,
S.-f. Lin ,
A. Deo ,
N. Price ,
M. Wood ,
T. Lara-Jaime ,
F. Montel ,
M. Laruelle ,
R. E. Carson ,
J. Hannestad ,
Y. Huang
May 02 2016
February 04 2016
Read this article at
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
The synaptic vesicle glycoprotein 2A (SV2A) is found in secretory vesicles in neurons
and endocrine cells. PET with a selective SV2A radiotracer will allow characterization
of drugs that modulate SV2A (e.g., antiepileptic drugs) and potentially could be a
biomarker of synaptic density (e.g., in neurodegenerative disorders). Here we describe
the synthesis and characterization of the SV2A PET radiotracer (11)C-UCB-J ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one)
in nonhuman primates, including whole-body biodistribution.