Medium-Ring Nitrogen Heterocycles through Migratory Ring Expansion of Metalated Ureas

Hall, Jessica E.; Matlock, Johnathan V; Ward, John W; Gray, Katharine V.; Clayden, Jonathan D

doi:10.1002/anie.201605714

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Medium-Ring Nitrogen Heterocycles through Migratory Ring Expansion of Metalated Ureas

Author(s): Jessica E. Hall , Johnathan V. Matlock , John W. Ward , Katharine V. Gray , Jonathan Clayden

Publication date Created: September 05 2016

Publication date (Print): September 05 2016

Journal: Angewandte Chemie International Edition

Publisher: Wiley-Blackwell

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Privileged scaffolds for library design and drug discovery.

Matthew E Welsch, Scott A. Snyder, Brent Stockwell (2010)

This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited. Copyright 2010 Elsevier Ltd. All rights reserved.