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      RNA-based antiviral immunity.

      Nature reviews. Immunology

      Animals, Humans, RNA, Small Interfering, genetics, immunology, RNA, Viral, Virus Diseases

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          Abstract

          In eukaryotic RNA-based antiviral immunity, viral double-stranded RNA is recognized as a pathogen-associated molecular pattern and processed into small interfering RNAs (siRNAs) by the host ribonuclease Dicer. After amplification by host RNA-dependent RNA polymerases in some cases, these virus-derived siRNAs guide specific antiviral immunity through RNA interference and related RNA silencing effector mechanisms. Here, I review recent studies on the features of viral siRNAs and other virus-derived small RNAs from virus-infected fungi, plants, insects, nematodes and vertebrates and discuss the innate and adaptive properties of RNA-based antiviral immunity.

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          Author and article information

          Journal
          20706278
          10.1038/nri2824

          Chemistry

          Animals, Humans, RNA, Small Interfering, genetics, immunology, RNA, Viral, Virus Diseases

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