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      Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3.

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          Abstract

          To examine the mechanism of interleukin-1 (IL-1)-induced collagenase 3 (matrix metalloproteinase 13 [MMP-13]) gene expression in cultured chondrocytes for the purpose of better understanding how the gene is induced in these cells, and how it contributes to cartilage degradation in osteoarthritis.

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          Author and article information

          Journal
          Arthritis Rheum
          Arthritis and rheumatism
          Wiley
          0004-3591
          0004-3591
          Apr 2000
          : 43
          : 4
          Affiliations
          [1 ] Dartmouth Medical School, Hanover, NH 03755, USA.
          Article
          10.1002/1529-0131(200004)43:4<801::AID-ANR10>3.0.CO;2-4
          10765924
          61d59d39-20dc-439d-970f-b751add865ab
          History

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