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      Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance

      review-article
      Author(s): 1 , 2 , *
      Publication date (Electronic):
      Journal: Cancers
      Publisher: MDPI
      Keywords: membrane transporters, pumps, ion channels, cancers, chemoresistance

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          Abstract

          Improving the therapeutic efficacy of conventional anticancer drugs represents the best hope for cancer treatment. However, the shortage of druggable targets and the increasing development of anticancer drug resistance remain significant problems. Recently, membrane transport proteins have emerged as novel therapeutic targets for cancer treatment. These proteins are essential for a plethora of cell functions ranging from cell homeostasis to clinical drug toxicity. Furthermore, their association with carcinogenesis and chemoresistance has opened new vistas for pharmacology-based cancer research. This review provides a comprehensive update of our current knowledge on the functional expression profile of membrane transport proteins in cancer and chemoresistant tumours that may form the basis for new cancer treatment strategies.

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          Most cited references265

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          TRP channels as cellular sensors.

          David Clapham (2003)
          TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.
          Article 0 comments Cited 587 times – based on 0 reviews     Review now
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            Voltage-gated calcium channels.

            William Catterall (2011)
            Voltage-gated calcium (Ca(2+)) channels are key transducers of membrane potential changes into intracellular Ca(2+) transients that initiate many physiological events. There are ten members of the voltage-gated Ca(2+) channel family in mammals, and they serve distinct roles in cellular signal transduction. The Ca(V)1 subfamily initiates contraction, secretion, regulation of gene expression, integration of synaptic input in neurons, and synaptic transmission at ribbon synapses in specialized sensory cells. The Ca(V)2 subfamily is primarily responsible for initiation of synaptic transmission at fast synapses. The Ca(V)3 subfamily is important for repetitive firing of action potentials in rhythmically firing cells such as cardiac myocytes and thalamic neurons. This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties.
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              Calcium and cancer: targeting Ca2+ transport.

              Gregory Monteith, Damara McAndrew, Helen M. Faddy … (2007)
              Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted?
              Article 0 comments Cited 233 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Cancers (Basel)
                Journal ID (iso-abbrev): Cancers (Basel)
                Journal ID (publisher-id): cancers
                Title: Cancers
                Publisher: MDPI
                ISSN (Electronic): 2072-6694
                Publication date (Electronic): 19 June 2020
                Publication date Collection: June 2020
                Volume: 12
                Issue: 6
                Electronic Location Identifier: 1624
                Affiliations
                [1 ]Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON KIH 8M5, Canada; salmasi@ 123456uottawa.ca
                [2 ]Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada
                Author notes
                Author information
                https://orcid.org/0000-0002-3631-5931
                Article
                Publisher ID: cancers-12-01624
                DOI: 10.3390/cancers12061624
                PMC ID: 7353007
                PubMed ID: 32575381
                SO-VID: 61d90967-5652-4f85-91b8-f608091defc0
                Copyright © © 2020 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 09 June 2020
                Date accepted : 16 June 2020
                Categories
                Subject: Review

                Keywords: membrane transporters,pumps,ion channels,cancers,chemoresistance
                Data availability:
                Keywords: membrane transporters, pumps, ion channels, cancers, chemoresistance

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