The TetO rat as a new translational model for type 2 diabetic retinopathy by inducible insulin receptor knockdown.

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Abstract

Although the renin-angiotensin system plays an important role in the progression of diabetic retinopathy, its influence therein has not been systematically evaluated. Here we test the suitability of a new translational model of diabetic retinopathy, the TetO rat, for addressing the role of angiotensin-II receptor 1 (AT1) blockade in experimental diabetic retinopathy.

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Journal

Journal ID (iso-abbrev): Diabetologia

Title: Diabetologia

Publisher: Springer Nature

ISSN (Electronic): 1432-0428

ISSN (Print): 0012-186X

Publication date (Electronic): Jan 2017

Volume: 60

Issue: 1

Affiliations

[1 ] Department of Ophthalmology, Charité-Universitätsmedizin Berlin Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany. nadine.reichhart@charite.de.

[2 ] Department of Ophthalmology, Charité-Universitätsmedizin Berlin Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.

[3 ] Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité-Universitätsmedizin Berlin, Berlin, Germany.

[4 ] Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

[5 ] Berlin Institute of Health, Berlin, Germany.

[6 ] Department of Obstetrics, Charité-Universitätsmedizin Berlin Campus Virchow Klinikum, Berlin, Germany.

[7 ] Department of Gynecology, Charité-Universitätsmedizin Berlin Campus Virchow Klinikum, Berlin, Germany.

[8 ] Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.

[9 ] German Center for Cardiovascular Disease, Berlin, Germany.

[10 ] Department of Biology, Universität zu Lübeck, Lübeck, Germany.

[11 ] Charité-Universitätsmedizin Berlin Campus Berlin-Buch, Berlin, Germany.

[12 ] Department of Cardiology and Nephrology, HELIOS Klinikum Berlin-Buch, Berlin, Germany.

[13 ] Department of Ophthalmology, Charité-Universitätsmedizin Berlin Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany. antonia.joussen@charite.de.

Article

Publisher Item ID: 10.1007/s00125-016-4115-0

DOI: 10.1007/s00125-016-4115-0

PubMed ID: 27704165

SO-VID: 61e23ee6-d277-419e-aa0c-c1b4f4e5f99e

History

Keywords: Angiotensin-II receptor 1 blockade,Experimental diabetic retinopathy,Neurodegeneration,Translational model,Type 2 diabetes

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Keywords: Angiotensin-II receptor 1 blockade, Experimental diabetic retinopathy, Neurodegeneration, Translational model, Type 2 diabetes

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