17
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Metastatic spermatocytic seminoma. A case report with light microscopic, ultrastructural, and immunohistochemical findings.

      Lancet
      Dysgerminoma, secondary, therapy, ultrastructure, Humans, Lymphatic Metastasis, Male, Middle Aged, Orchiectomy, Retroperitoneal Neoplasms, Staining and Labeling, Testicular Neoplasms, pathology

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A case of metastatic spermatocytic seminoma with metastases to homolateral retroperitoneal paraaortic lymph nodes in a 50-year-old man is described. The metastases were detected 18 months after orchiectomy. A retroperitoneal biopsy with cytoreductive lymphadenectomy was performed followed by radiotherapy and consecutively by combination chemotherapy. The patient died 25 months after orchiectomy of complications arising after a second course of chemotherapy. No signs of further tumor spread were observed. Autopsy was not performed. The tissue of the metastases fulfilled the light microscopic criteria for spermatocytic seminoma and ultrastructurally showed intercellular communications with typical intercellular bridges. The absence of placental alkaline phosphatase in tumor cells is also consistent with this diagnosis. The metastases differed from the primary tumor in the presence of focal lymphocytic infiltration and granulomatous reaction. This patient represents the first fully documented case of a metastasizing spermatocytic seminoma.

          Related collections

          Author and article information

          Journal
          2457427
          10.1002/1097-0142(19880915)62:6<1197::AID-CNCR2820620626>3.0.CO;2-A

          Chemistry
          Dysgerminoma,secondary,therapy,ultrastructure,Humans,Lymphatic Metastasis,Male,Middle Aged,Orchiectomy,Retroperitoneal Neoplasms,Staining and Labeling,Testicular Neoplasms,pathology

          Comments

          Comment on this article