Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: a comparative study.

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Abstract

Antibodies have been implicated in the pathogenicity of multiple sclerosis by findings of immunoglobulins in patients' CSF and often IgG and complement in lesions, and by a 2012 report that nearly half of patients' serum samples contain IgG specific for a glial potassium-channel, KIR4.1. We aimed to establish the frequency of KIR4.1-binding IgG in serum and CSF of patients with multiple sclerosis, and whether KIR4.1 immunoreactivity is retained or lost in demyelinating lesions.

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Journal

Journal ID (iso-abbrev): Lancet Neurol

Title: The Lancet. Neurology

ISSN (Electronic): 1474-4465

ISSN (Print): 1474-4422

Publication date (Electronic): Aug 2014

Volume: 13

Issue: 8

Affiliations

[1 ] Department of Immunology, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.

[2 ] Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

[3 ] Department of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

[4 ] Department of Neurology, Mayo Clinic, Rochester, MN, USA.

[5 ] Department of Neurology, University of Wuerzburg, Germany.

[6 ] Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.

[7 ] Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

[8 ] Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

[9 ] Pierre Zobda Quitman Hospital, CHRU de Fort de France, Martinique.

[10 ] Department of Immunology, Mayo Clinic, Rochester, MN, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: lennon.vanda@mayo.edu.

Article

Publisher Item ID: S1474-4422(14)70141-3 Mid ID: NIHMS614090

DOI: 10.1016/S1474-4422(14)70141-3

PubMed ID: 25008548

SO-VID: 61fa4831-809d-4264-a2bd-a8dbe725f493

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