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      Taming the complexity of protein folding.

      Current Opinion in Structural Biology

      Computational Biology, Humans, Models, Molecular, Protein Folding, Proteins, chemistry, metabolism

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          Abstract

          Protein folding is an important problem in structural biology with significant medical implications, particularly for misfolding disorders like Alzheimer's disease. Solving the folding problem will ultimately require a combination of theory and experiment, with theoretical models providing a comprehensive view of folding and experiments grounding these models in reality. Here we review progress towards this goal over the past decade, with an emphasis on recent theoretical advances that are empowering chemically detailed models of folding and the new results these technologies are providing. In particular, we discuss new insights made possible by Markov state models (MSMs), including the role of non-native contacts and the hub-like character of protein folded states. Copyright © 2010 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          21081274
          3042729
          10.1016/j.sbi.2010.10.006

          Chemistry

          Computational Biology, Humans, Models, Molecular, Protein Folding, Proteins, chemistry, metabolism

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