For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
12
views
40
references
 Top references
cited by
1
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      666
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      The Efficacy and Safety of Nicorandil for Periprocedural Myocardial Injury in Patients Undergoing PCI: A Meta-Analysis

      research-article
      Author(s): , , ,
      Publication date (Electronic):
      Journal: Journal of Interventional Cardiology
      Publisher: Hindawi

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Purpose

          To evaluate the efficacy and safety of nicorandil for periprocedural myocardial injury in patients undergoing PCI through meta-analysis of randomized controlled trials.

          Methods

          We analyzed the clinical data of patients including the incidence of periprocedural myocardial injury (PMI) and major adverse cardiovascular events (MACE) from selected articles. RCTs were retrieved from medical literature databases. RR and 95% confidence intervals (CI) were calculated to compare the endpoints.

          Results

          In total, 15 articles (16 trial comparisons) were retrieved which contained 2221 patients. In general, 1130 patients (50.9%) were randomized to the experimental group, whereas 1091 patients (49.1%) were randomized to the control group. The result showed that nicorandil significantly reduced the incidence of PMI and MACE after PCI compared to the control group.

          Conclusions

          Overall, early use of nicorandil in patients undergoing percutaneous coronary intervention (PCI) was associated with a significant reduction of PMI and MACE.

          Related collections

          Most cited references40

          • Record: found
          • Abstract: not found
          • Article: not found

          RoB 2: a revised tool for assessing risk of bias in randomised trials

          Jonathan A C Sterne, Jelena Savović, Matthew J L Page … (2022)
          Article 0 comments Cited 5447 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

            David Moher, Alessandro Liberati, Jennifer Tetzlaff … (2011)
            David Moher and colleagues introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses
            Article 0 comments Cited 4879 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Peri-procedural myocardial injury during percutaneous coronary intervention: an important target for cardioprotection.

              Bruce Walker, Steven Yellon, G Babu … (2010)
              Percutaneous coronary intervention (PCI) has become the predominant procedure for coronary revascularization in patients with both stable and unstable coronary artery disease (CAD). Over the past two decades, technical advances in PCI have resulted in a better and safer therapeutic procedure with minimal procedural complications. However, about 30% of patients undergoing elective PCI sustain myocardial injury arising from the procedure itself, the extent of which is significant enough to carry prognostic importance. The peri-procedural injury which accompanies PCI might therefore reduce some of the beneficial effects of coronary revascularization. The availability of more sensitive serum biomarkers of myocardial injury such as creatine phosphokinase MB isoenzyme (CK-MB), Troponin T, and Troponin I has enabled the quantification of previously undetectable myocardial injury. Peri-procedural myocardial injury (PMI) can also be visualized by cardiac magnetic resonance imaging, a technique which allows the detection and quantification of myocardial necrosis following PCI. The identification of CAD patients at greatest risk of sustaining PMI during PCI would allow targeted treatment with novel therapies capable of limiting the extent of PMI or reducing the number of patients experiencing PMI.
              Article 0 comments Cited 46 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Qiwu Wang:
                ORCID: https://orcid.org/0000-0001-9088-2702
                Journal
                Journal ID (nlm-ta): J Interv Cardiol
                Journal ID (iso-abbrev): J Interv Cardiol
                Journal ID (publisher-id): JITC
                Title: Journal of Interventional Cardiology
                Publisher: Hindawi
                ISSN (Print): 0896-4327
                ISSN (Electronic): 1540-8183
                Publication date Collection: 2020
                Publication date (Electronic): 6 November 2020
                Volume: 2020
                Electronic Location Identifier: 3293587
                Affiliations
                Department of Cardiology, The Second People's Hospital of Nanning, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
                Author notes

                Academic Editor: Jochen Wöhrle

                Author information
                https://orcid.org/0000-0001-9088-2702
                Article
                DOI: 10.1155/2020/3293587
                PMC ID: 7665917
                SO-VID: 6202f289-a319-444f-9001-a9d3da7f5f27
                Copyright © Copyright © 2020 Yuanxi Lu et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 5 June 2020
                Date revision received : 1 October 2020
                Date accepted : 27 October 2020
                Categories
                Subject: Research Article

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content666

                See all similar

                Cited by1

                See all cited by

                Most referenced authors1,058

                See all reference authors