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      Flexible Graphene Electrodes for Prolonged Dynamic ECG Monitoring

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          Abstract

          This paper describes the development of a graphene-based dry flexible electrocardiography (ECG) electrode and a portable wireless ECG measurement system. First, graphene films on polyethylene terephthalate (PET) substrates and graphene paper were used to construct the ECG electrode. Then, a graphene textile was synthesized for the fabrication of a wearable ECG monitoring system. The structure and the electrical properties of the graphene electrodes were evaluated using Raman spectroscopy, scanning electron microscopy (SEM), and alternating current impedance spectroscopy. ECG signals were then collected from healthy subjects using the developed graphene electrode and portable measurement system. The results show that the graphene electrode was able to acquire the typical characteristics and features of human ECG signals with a high signal-to-noise (SNR) ratio in different states of motion. A week-long continuous wearability test showed no degradation in the ECG signal quality over time. The graphene-based flexible electrode demonstrates comfortability, good biocompatibility, and high electrophysiological detection sensitivity. The graphene electrode also combines the potential for use in long-term wearable dynamic cardiac activity monitoring systems with convenience and comfort for use in home health care of elderly and high-risk adults.

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          Most cited references28

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          High-throughput solution processing of large-scale graphene.

          The electronic properties of graphene, such as high charge carrier concentrations and mobilities, make it a promising candidate for next-generation nanoelectronic devices. In particular, electrons and holes can undergo ballistic transport on the sub-micrometre scale in graphene and do not suffer from the scale limitations of current MOSFET technologies. However, it is still difficult to produce single-layer samples of graphene and bulk processing has not yet been achieved, despite strenuous efforts to develop a scalable production method. Here, we report a versatile solution-based process for the large-scale production of single-layer chemically converted graphene over the entire area of a silicon/SiO(2) wafer. By dispersing graphite oxide paper in pure hydrazine we were able to remove oxygen functionalities and restore the planar geometry of the single sheets. The chemically converted graphene sheets that were produced have the largest area reported to date (up to 20 x 40 microm), making them far easier to process. Field-effect devices have been fabricated by conventional photolithography, displaying currents that are three orders of magnitude higher than previously reported for chemically produced graphene. The size of these sheets enables a wide range of characterization techniques, including optical microscopy, scanning electron microscopy and atomic force microscopy, to be performed on the same specimen.
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            A Stretchable and Highly Sensitive Graphene-Based Fiber for Sensing Tensile Strain, Bending, and Torsion.

            Wearable sensors are increasingly finding their way into applications of kinesthetic sensing, personal health monitoring, and smart prosthetics/robotics. A graphene-based composite fiber sensor with a "compression spring" structure is fabricated, featuring the ability of detecting multiple kinds of deformation. This fiber sensor is integrated into wearable sensors for monitoring human activities and intricate movements of robotics successfully.
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              Graphene, the new nanocarbon

                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Sensors (Basel)
                Sensors (Basel)
                sensors
                Sensors (Basel, Switzerland)
                MDPI
                1424-8220
                01 November 2016
                November 2016
                : 16
                : 11
                : 1833
                Affiliations
                [1 ]Department of Biomedical Engineering, College of Electronic Information Engineering & Key Laboratory of Digital Medical Engineering of Hebei Province, Hebei University, Baoding 071002, China; loucunguang@ 123456163.com (C.L.); 15031286182@ 123456163.com (R.L.); 15712590824@ 123456163.com (Z.L.); lanswer@ 123456163.com (T.L.)
                [2 ]College of Quality and Technical Supervision, Hebei University, Baoding 071002, China; zihui-wei@ 123456163.com
                [3 ]College of Chemistry & Environment Science, Hebei University, Baoding 071002, China; lhbx@ 123456hbu.edu.cn
                [4 ]Department of Electronic Science and Technology, College of Electronic Information Engineering & Key Laboratory of Digital Medical Engineering of Hebei province, Hebei University, Baoding 071002, China; xiaobing_yan@ 123456126.com
                Author notes
                [* ]Correspondence: liuxiuling121@ 123456hotmail.com ; Tel.: +86-312-5079-483
                Article
                sensors-16-01833
                10.3390/s16111833
                5134492
                27809270
                62198d5c-1b79-4bf1-9b70-125492676a4d
                © 2016 by the authors; licensee MDPI, Basel, Switzerland.

                This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 12 July 2016
                : 28 October 2016
                Categories
                Article

                Biomedical engineering
                graphene,ecg,flexible electrode,home health
                Biomedical engineering
                graphene, ecg, flexible electrode, home health

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