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      Effect of Thiourea on Intracranial Bone Tumour Formation in AkR Mice

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      Hormone Research in Paediatrics

      S. Karger AG

      Pituitary, Thiourea, Thyroxine, Hyperplastic benign osteoma

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          The effect of administration of thiourea (5 g/kg in diet) alone or simultaneously with thyroxine (1 mg/l in drinking water) on the frequency of hyperplastic benign osteoma of the skull was studied in AkR mice. Animals treated with both thiourea and thyroxine were in hyperthyroidism: the thyroxine dose received was higher than that required to prevent thiourea-induced thyroid gland hypertrophy. A significant increase of the intracranial bone tumour (IBT) frequency was observed both in mice treated with thiourea alone and those which received thiourea and thyroxine simultaneously. Increase of IBT frequency was not due to the antithyroid effect of thiourea but seems due to a direct toxic action of thiourea on the pituitary.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 10
          : 2-3
          : 79-87
          Unite de cancérologie expérimentale (U 119 Inserm), Marseille, and Laboratoire de génétique (Equipe de Recherche 190 du CNRS), Fondation Curie, Institut du radium, Paris
          178991 Horm Res 1979;10:79–87
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 9


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