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      Size Changes of Auxiliary Adult Heart Grafts in Rats

      ,

      Cardiology

      S. Karger AG

      Transplantation, Atrophy, Hypertrophy, Chondrification, Ossification, Heart

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          Abstract

          Extra adult rat hearts were transplanted isologously into the abdominal cavities to study their growth reactions. The aorta and pulmonary artery of the donor heart were sutured to the host aorta and inferior vena cava by end-to-side anastomoses, the donor veins being ligated. Such hearts pumped blood from the aorta through the coronary circulation and the right auricle and ventricle. After 2 months to 1 year, about one third of the 62 grafts had undergone atrophy, losing up to two thirds of their original weights at transplantation but retaining nearly normal LV/RV ratios. Of the remaining grafts, 16 had not changed in weight, while 8 had hypertrophied due primarily to the growth of the right ventricular wall. About one quarter of the transplants were grossly abnormal owing to necrosis or osteogenesis.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1973
          1973
          29 October 2008
          : 58
          : 6
          : 355-363
          Affiliations
          Department of Anatomy, Boston University School of Medicine, Boston, Mass., and the Division of Biological and Medical Sciences, Brown University, Providence, R.I.
          Article
          169653 Cardiology 1973;58:355–363
          10.1159/000169653
          4278377
          © 1973 S. Karger AG, Basel

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          Page count
          Pages: 9
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