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Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis.
Yvonne Döring
1 ,
Helga D Manthey ,
Maik Drechsler ,
Dirk Lievens ,
Remco T A Megens ,
Oliver Soehnlein ,
Martin Busch ,
Marco Manca ,
Rory R Koenen ,
Jaroslav Pelisek ,
Mat J Daemen ,
Esther Lutgens ,
Martin Zenke ,
Christoph J Binder ,
Christian Weber ,
Alma Zernecke
Apr 03 2012
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Abstract
Inflammation has been closely linked to auto-immunogenic processes in atherosclerosis. Plasmacytoid dendritic cells (pDCs) are specialized to produce type-I interferons in response to pathogenic single-stranded nucleic acids, but can also sense self-DNA released from dying cells or in neutrophil extracellular traps complexed to the antimicrobial peptide Cramp/LL37 in autoimmune disease. However, the exact role of pDCs in atherosclerosis remains elusive.