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      Immunologic Aspects of Chronic Fatigue Syndrome

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          Abstract

          Chronic fatigue syndrome (CFS) is a serious health concern affecting over 800,000 Americans of all ages, races, socioeconomic groups and genders. The etiology and pathophysiology of CFS are unknown, yet studies have suggested an involvement of the immune system. A symposium was organized in October 2001 to explore the possibility of an association between immune dysfunction and CFS, with special emphasis on the interactions between immune dysfunction and other abnormalities noted in the neuroendocrine and autonomic nervous systems of individuals with CFS. This paper represents the consensus of the panel of experts who participated in this meeting. Data suggest that persons with CFS manifest changes in immune responses that fall outside normative ranges, but current research does not provide definitive evidence on whether these immune abnormalities are a cause or result of the illness. It has become clear that CFS cannot be understood based on single measurements of immune, endocrine, cardiovascular, or autonomic nervous system dysfunction. This panel encourages a new emphasis on multidisciplinary research into CFS.

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          A Community-Based Study of Chronic Fatigue Syndrome

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            Author and article information

            Journal
            NIM
            Neuroimmunomodulation
            10.1159/issn.1021-7401
            Neuroimmunomodulation
            S. Karger AG
            1021-7401
            1423-0216
            2004
            October 2004
            13 October 2004
            : 11
            : 6
            : 351-357
            Affiliations
            aWorcester Polytechnic Institute, Worcester, Mass., bEmory University, Atlanta, Ga., cUniversity of Pennsylvania, Philadelphia, Pa., dDepartment of Veterans Affairs, Perry Point, Md., USA; eSt. Bartholomew’s Hospital and Royal London School of Medicine and Dentistry, London, UK; fResearch Methodologist (Ret.), Cobb Island, Md., gUniversity of Pittsburgh, Pittsburgh, Pa., hUniversity of Texas Health Science Center at Houston, Houston, Tex., iPrivate Practice, New York, N.Y., jSRI International, Menlo Park, Calif., kHyde Park, N.Y., lUniversity of Medicine & Dentistry of New Jersey, Netwark, N.J., mUniversity of the Pacific, Stockton, Calif., USA
            Article
            80144 Neuroimmunomodulation 2004;11:351–357
            10.1159/000080144
            15467349
            © 2004 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            References: 3, Pages: 7
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