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      miR-190a inhibits epithelial-mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA.

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          Abstract

          treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal-epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR-190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR-190a-treRNA axis in hepatoma progression and shed light on lncRNA-based cancer therapies for hepatoma patients at high risk of metastasis.

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          Author and article information

          Journal
          FEBS Lett.
          FEBS letters
          Elsevier BV
          1873-3468
          0014-5793
          Dec 21 2015
          : 589
          : 24 Pt B
          Affiliations
          [1 ] State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China; Department of Genetics, Harvard Medical School, Boston, MA, USA.
          [2 ] State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
          [3 ] Department of Radiation Oncology, Huaian No. 2 Hospital, Huaian, Jiangsu Province, China.
          [4 ] State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China. Electronic address: yangm@mail.buct.edu.cn.
          Article
          S0014-5793(15)01028-5
          10.1016/j.febslet.2015.11.024
          26608035
          62481ce0-bc1d-40fa-8e38-c9638998ffae
          History

          Epithelial-to-mesenchymal transition,Hepatoma,Long non-coding RNA,Translation regulatory long non-coding RNA,miR-190a

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