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      Prolonged Neuroendocrine Effects of a Brief Exposure of Adult Male Rats to Diethylstilbestrol

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          Abstract

          Eleven weeks of exposure to diethylstilbestrol (DES) releasing capsules caused marked changes in neuroendocrine function in male rats sacrificed 22 months later. Plasma prolactin levels were increased and plasma LH levels were decreased in the DES-exposed as compared to the control animals. DES-treated animals had significantly decreased levels of dopamine (DA) in the median eminence and lower rates of DOPA accumulation after blockade of aromatic amino acid decarboxylase than did the control animals. Norepinephrine and serotonin content and 5-hydroxytryptophan content in the ME, the medial basal and the anterior hypothalamus were not significantly affected by DES treatment. Basal prolactin release in vitro was reduced in the DES animals while prolactin responsiveness to inhibitory effects of 10<sup>–7</sup> M DA was enhanced. From these data it appears that a relatively brief exposure to DES in early adulthood causes marked and persistent changes in tuberoinfundibular DA function that are responsible for continued hyperprolactinemia. Associated reductions in LH secretion also appear to be due to hypothalamic as opposed to pituitary factors.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1989
          1989
          02 April 2008
          : 49
          : 2
          : 191-196
          Affiliations
          aDepartment of Physiology, School of Medicine, Southern Illinois University, Carbondale, Ill., USA; bDepartment of Biochemistry, Faculty of Medicine Complutense University, Madrid, Spain
          Article
          125113 Neuroendocrinology 1989;49:191–196
          10.1159/000125113
          2725837
          © 1989 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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