4
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      N-Acetylcysteine Protects against the Anxiogenic Response to Cisplatin in Rats

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Since cisplatin therapy is usually accompanied with numerous toxicities, including neurotoxicity, that involve tissue oxidative damage, the aim of this study was to evaluate the possible protective effect of N-acetylcysteine (NAC) on the anxiogenic response to cisplatin (CIS). Thirty-two male Wistar albino rats divided into four groups (control, cisplatin, NAC, and CIS + NAC). All treatments were delivered intraperitoneally. On day one, the control and cisplatin groups received saline while the NAC and CIS + NAC groups were administered with NAC (500 mg/kg). On the fifth day, the control group received saline while the CIS group was treated with cisplatin (7.5 mg/kg), the NAC group again received NAC (500 mg/kg), and the CIS + NAC group was simultaneously treated with cisplatin and NAC (7.5 and 500 mg/kg, respectively). Behavioral testing, performed on the tenth day in the open field (OF) and elevated plus maze (EPM) tests, revealed the anxiogenic effect of cisplatin that was significantly attenuated by NAC. The hippocampal sections evaluation showed increased oxidative stress (increased lipid peroxidation and decline in antioxidant enzymes activity) and proapoptotic action (predominantly by diminished antiapoptotic gene expression) following a single dose of cisplatin. NAC supplementation along with cisplatin administration reversed the prooxidative and proapoptotic effects of cisplatin. In conclusion, the results obtained in this study confirmed that antioxidant supplementation with NAC may attenuate the cisplatin-induced anxiety. The mechanism of anxiolytic effect achieved by NAC may include the decline in oxidative damage that down regulates increased apoptosis and reverses the anxiogenic action of cisplatin.

          Related collections

          Most cited references29

          • Record: found
          • Abstract: not found
          • Article: not found

          A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Apoptosis in neurodegenerative disorders.

            Neuronal death underlies the symptoms of many human neurological disorders, including Alzheimer's, Parkinson's and Huntington's diseases, stroke, and amyotrophic lateral sclerosis. The identification of specific genetic and environmental factors responsible for these diseases has bolstered evidence for a shared pathway of neuronal death--apoptosis--involving oxidative stress, perturbed calcium homeostasis, mitochondrial dysfunction and activation of cysteine proteases called caspases. These death cascades are counteracted by survival signals, which suppress oxyradicals and stabilize calcium homeostasis and mitochondrial function. With the identification of mechanisms that either promote or prevent neuronal apoptosis come new approaches for preventing and treating neurodegenerative disorders.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              INHIBITION OF CELL DIVISION IN ESCHERICHIA COLI BY ELECTROLYSIS PRODUCTS FROM A PLATINUM ELECTRODE.

                Bookmark

                Author and article information

                Journal
                Biomolecules
                Biomolecules
                biomolecules
                Biomolecules
                MDPI
                2218-273X
                17 December 2019
                December 2019
                : 9
                : 12
                : 892
                Affiliations
                [1 ]Clinic for Anesthesiology and Critical Care, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia; radvuk@ 123456gmail.com
                [2 ]Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia; ikumburovic@ 123456gmail.com (I.K.); jovana_joksimovic@ 123456yahoo.com (J.J.J.)
                [3 ]Department of Histology and Embryology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia; nemanjajovicic.kg@ 123456gmail.com
                [4 ]Department of Science, Institute for Information Technologies Kragujevac, University of Kragujevac, Jovana Cvijica b.b., 34000 Kragujevac, Serbia; jkatanic@ 123456kg.ac.rs
                [5 ]Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia; vladimir.mihailovic@ 123456pmf.kg.ac.rs
                [6 ]Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia; dr.milosdj@ 123456gmail.com
                [7 ]Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia; velickovicstefan91@ 123456gmail.com (S.V.); sandra11_92@ 123456yahoo.com (A.A.)
                Author notes
                Author information
                https://orcid.org/0000-0003-1697-8380
                Article
                biomolecules-09-00892
                10.3390/biom9120892
                6995611
                31861240
                628004bf-2296-4dd3-ae5b-5c70d442fae1
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 13 November 2019
                : 08 December 2019
                Categories
                Article

                cisplatin,n-acetylcysteine,oxidative stress,apoptosis,hippocampus,rats

                Comments

                Comment on this article