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      Comparison of the effects of captopril and enalapril on oxyphenbutazone and ethanol-induced gastric lesions in rats.

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          Abstract

          We have compared the effect of the converting enzyme inhibitors, captopril and enalapril, on two models of gastric ulcers, viz; ethanol and oxyphenbutazone-induced lesions in rats. Both captopril and enalapril did not affect ethanol-induced lesions. While captopril significantly protected against oxyphenbutazone-induced lesions, enalapril aggravated the lesions. This difference is probably due to the lack of the protective sulfhydryl group in the chemical structure of enalapril.

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          Author and article information

          Journal
          Indian J. Physiol. Pharmacol.
          Indian journal of physiology and pharmacology
          0019-5499
          0019-5499
          Jul 1990
          : 34
          : 3
          Affiliations
          [1 ] Department of Pharmacology, Goa Medical College, Bambolin.
          Article
          2286425

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