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      Brain lactate uptake increases at the site of impact after traumatic brain injury

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      Brain Research

      Elsevier BV

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          Abstract

          Although glucose is the main carbohydrate energy substrate for the normal brain, several studies published over the last 10 years now challenge this assumption. The activated brain increases its metabolism to meet increased energy demands by glycolysis after injury. In vitro studies now show that lactate alone can serve as an energy source to maintain synaptic function. In this study, we used 14C-lactate to test the hypothesis that blood lactate is acutely taken up by the injured brain, after fluid percussion injury (FPI) in the rat. 50 microCi radioactive lactate was injected i.v. immediately after FPI, in injured and sham rats. After 30 min, the brain was removed, frozen, and cut into 20 microm sections for autoradiography. Uptake of 14C-label was mainly concentrated at the injury site (2.5 times greater) although uninjured brain also took up the 14C-label. This increased concentration of radioactive lactate at the injury site suggests that the injured brain may use the lactate as an energy source.

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          Author and article information

          Journal
          Brain Research
          Brain Research
          Elsevier BV
          00068993
          April 2000
          April 2000
          : 861
          : 2
          : 281-287
          Article
          10.1016/S0006-8993(00)01992-2
          10760489
          © 2000

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