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      Experimental Membranous Glomerulonephritis

      ,

      Nephron

      S. Karger AG

      Membranous glomerulonephritis, Free antibody, Circulating immune complexes

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          Abstract

          Active Heymann’s nephritis was induced in Wistar rats by a single injection of human renal tubular epithelial antigen (FXIA) and the animals were followed for 1 year. Correlations were made between circulating anti-FXIA antibody, circulating immune complexes (CIC) and pathology. The disease progressed pathologically through all stages of membranous nephropathy associated with a high level of free antibody but without significant detectable CIC, suggesting that the dominant disease mechanism may be the reaction between circulating free antibody and a fixed glomerular antigen rather than the deposition of CIC.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 31
          : 3
          : 260-265
          Affiliations
          Department of Medicine, University of Toronto, and University of Western Ontario, London, Ont, Canada
          Article
          182656 Nephron 1982;31:260–265
          10.1159/000182656
          6214723
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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