Experimental Membranous Glomerulonephritis

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Abstract

Active Heymann’s nephritis was induced in Wistar rats by a single injection of human renal tubular epithelial antigen (FXIA) and the animals were followed for 1 year. Correlations were made between circulating anti-FXIA antibody, circulating immune complexes (CIC) and pathology. The disease progressed pathologically through all stages of membranous nephropathy associated with a high level of free antibody but without significant detectable CIC, suggesting that the dominant disease mechanism may be the reaction between circulating free antibody and a fixed glomerular antigen rather than the deposition of CIC.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1982

Publication date (Print): 1982

Publication date (Electronic): 03 December 2008

Volume: 31

Issue: 3

Pages: 260-265

Affiliations

Department of Medicine, University of Toronto, and University of Western Ontario, London, Ont, Canada

Article

Publisher ID: 182656 Other ID: Nephron 1982;31:260–265

DOI: 10.1159/000182656

PubMed ID: 6214723

SO-VID: 629b2c65-3337-4ead-aa27-a6c1b04913c2

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 24 November 1981

Page count

Pages: 6

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