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      COVID-19 Pandemic and the Crisis of Health Systems: The Experience of the Apulia Cancer Network and of the Comprehensive Cancer Center Istituto Tumori “Giovanni Paolo II” of Bari

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          Abstract

          On 11 March 2020, the World Health Organization declared a new disease caused by a novel virus characterized by rapid human-to-human transmission and named severe acute respiratory syndrome coronoavirus-2 (SARS-CoV-2) a pandemic. In terms of this ongoing international scenario, we report the situation in Apulia, a region of southern Italy that, as of April 2, has not yet been overwhelmed by this health emergency. In particular, we consider the care models that have been adopted, especially those that manage the requests of cancer patients.

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          A Novel Coronavirus from Patients with Pneumonia in China, 2019

          Summary In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.)
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            What China’s coronavirus response can teach the rest of the world

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              Personalized Cancer Models for Target Discovery and Precision Medicine

              Although cancer research is progressing at an exponential rate, translating this knowledge to develop better cancer drugs and more effectively match drugs to patients is lagging. Genome profiling of tumors provides a snapshot of the genetic complexity of individual tumors, yet this knowledge is insufficient to guide therapy for most patients. Model systems -usually cancer cell lines or mice – have been instrumental in cancer research and drug development, but translation of results to the clinic is inefficient, in part, because these models do not sufficiently reflect the complexity and heterogeneity of human cancer. Here, we discuss the potential of combining genomics with high throughput functional testing of patient derived tumor cells to overcome key roadblocks in both drug target discovery and precision medicine.
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                Author and article information

                Journal
                Int J Environ Res Public Health
                Int J Environ Res Public Health
                ijerph
                International Journal of Environmental Research and Public Health
                MDPI
                1661-7827
                1660-4601
                16 April 2020
                April 2020
                : 17
                : 8
                : 2763
                Affiliations
                [1 ]IRCCS Istituto Tumori “Giovanni Paolo II” of Bari, 70124 Bari, Italy
                [2 ]Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
                [3 ]Inter-Institutional Department of Oncology, Apulian Cancer Network, 70124 Bari, Italy; antonio.moschetta@ 123456uniba.it
                [4 ]Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
                [5 ]Scientific Direction-IRCCS Istituto Tumori “Giovanni Paolo II” of Bari, 70124 Bari, Italy; a.paradiso@ 123456oncologico.bari.it
                [6 ]General Direction-IRCCS Istituto Tumori “Giovanni Paolo II” of Bari, 70124 Bari, Italy; a.delvino@ 123456libero.it
                Author notes
                Author information
                https://orcid.org/0000-0001-7814-7318
                Article
                ijerph-17-02763
                10.3390/ijerph17082763
                7216232
                32316337
                62c2613e-8745-4797-9e19-2a4e06d32ca7
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 04 April 2020
                : 15 April 2020
                Categories
                Brief Report

                Public health
                covid-19,pandemic,health system,cancer patient
                Public health
                covid-19, pandemic, health system, cancer patient

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