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      DNA Damage Response in Cisplatin-Induced Nephrotoxicity

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          Abstract

          Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side-effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and death, resulting in acute kidney injury (AKI). Recent studies have suggested that DNA damage and the associated DNA damage response (DDR) is an important pathogenic mechanism of AKI following cisplatin treatment. Activation of DDR may lead to cell cycle arrest and DNA repair for cell survival or, in the presence of severe injury, kidney cell death. Modulation of DDR may provide novel renoprotective strategies for cancer patients undergoing cisplatin chemotherapy.

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          Author and article information

          Journal
          0417615
          848
          Arch Toxicol
          Arch. Toxicol.
          Archives of toxicology
          0340-5761
          1432-0738
          18 November 2015
          13 November 2015
          December 2015
          01 December 2016
          : 89
          : 12
          : 2197-2205
          Affiliations
          [1 ]Institute of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
          [2 ]Departments of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN 38105
          [3 ]Department of Cellular Biology & Anatomy, Medical college of Georgia at Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, GA 30912
          Author notes
          [* ]Corresponding Author: Zheng Dong, PhD, Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Cellular Biology and Anatomy, Charlie Norwood VA Medical Center and Georgia Regents University, 1459 Laney Walker Blvd, Augusta, GA 30912. Phone: (706) 721-2825; Fax: (706) 721-6120; zdong@ 123456gru.edu
          Article
          PMC4734632 PMC4734632 4734632 nihpa738326
          10.1007/s00204-015-1633-3
          4734632
          26564230
          62c4e1b0-1e75-42d7-b18a-5346559b8088
          History
          Categories
          Article

          p53,Cisplatin,Nephrotoxicity,Apoptosis,Kidney,DNA damage
          p53, Cisplatin, Nephrotoxicity, Apoptosis, Kidney, DNA damage

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