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      Suprachiasmatic nucleus: cell autonomy and network properties.

      1 , ,
      Annual review of physiology
      Annual Reviews

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          Abstract

          The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals. Individual SCN neurons in dispersed culture can generate independent circadian oscillations of clock gene expression and neuronal firing. However, SCN rhythmicity depends on sufficient membrane depolarization and levels of intracellular calcium and cAMP. In the intact SCN, cellular oscillations are synchronized and reinforced by rhythmic synaptic input from other cells, resulting in a reproducible topographic pattern of distinct phases and amplitudes specified by SCN circuit organization. The SCN network synchronizes its component cellular oscillators, reinforces their oscillations, responds to light input by altering their phase distribution, increases their robustness to genetic perturbations, and enhances their precision. Thus, even though individual SCN neurons can be cell-autonomous circadian oscillators, neuronal network properties are integral to normal function of the SCN.

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          Author and article information

          Journal
          Annu Rev Physiol
          Annual review of physiology
          Annual Reviews
          1545-1585
          0066-4278
          2010
          : 72
          Affiliations
          [1 ] Department of Psychiatry, University of California-San Diego, La Jolla, CA 92093, USA. welshdk@ucsd.edu
          Article
          NIHMS503865
          10.1146/annurev-physiol-021909-135919
          3758475
          20148688
          62c79761-721b-4080-bc97-16af62d6d2fc
          History

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