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      Frailty in elderly people

      , , , ,
      The Lancet
      Elsevier BV

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          Abstract

          Frailty is the most problematic expression of population ageing. It is a state of vulnerability to poor resolution of homoeostasis after a stressor event and is a consequence of cumulative decline in many physiological systems during a lifetime. This cumulative decline depletes homoeostatic reserves until minor stressor events trigger disproportionate changes in health status. In landmark studies, investigators have developed valid models of frailty and these models have allowed epidemiological investigations that show the association between frailty and adverse health outcomes. We need to develop more efficient methods to detect frailty and measure its severity in routine clinical practice, especially methods that are useful for primary care. Such progress would greatly inform the appropriate selection of elderly people for invasive procedures or drug treatments and would be the basis for a shift in the care of frail elderly people towards more appropriate goal-directed care. Copyright © 2013 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          The Lancet
          The Lancet
          Elsevier BV
          01406736
          March 2013
          March 2013
          : 381
          : 9868
          : 752-762
          Article
          10.1016/S0140-6736(12)62167-9
          4098658
          23395245
          62d04976-6831-4e1a-bb17-a001fbe20948
          © 2013

          https://www.elsevier.com/tdm/userlicense/1.0/


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