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Frailty in elderly people
Author(s):
Andrew Clegg
,
John Young
,
Steve Iliffe
,
Marcel Olde Rikkert
,
Kenneth Rockwood
Publication date
Created:
March 2013
Publication date
(Print):
March 2013
Journal:
The Lancet
Publisher:
Elsevier BV
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PMC
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There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Frailty is the most problematic expression of population ageing. It is a state of vulnerability to poor resolution of homoeostasis after a stressor event and is a consequence of cumulative decline in many physiological systems during a lifetime. This cumulative decline depletes homoeostatic reserves until minor stressor events trigger disproportionate changes in health status. In landmark studies, investigators have developed valid models of frailty and these models have allowed epidemiological investigations that show the association between frailty and adverse health outcomes. We need to develop more efficient methods to detect frailty and measure its severity in routine clinical practice, especially methods that are useful for primary care. Such progress would greatly inform the appropriate selection of elderly people for invasive procedures or drug treatments and would be the basis for a shift in the care of frail elderly people towards more appropriate goal-directed care. Copyright © 2013 Elsevier Ltd. All rights reserved.
Related collections
UCL: UN SDG 03 Good Health and Well-Being
Author and article information
Journal
Title:
The Lancet
Abbreviated Title:
The Lancet
Publisher:
Elsevier BV
ISSN (Print):
01406736
Publication date Created:
March 2013
Publication date (Print):
March 2013
Volume
: 381
Issue
: 9868
Pages
: 752-762
Article
DOI:
10.1016/S0140-6736(12)62167-9
PMC ID:
4098658
PubMed ID:
23395245
SO-VID:
62d04976-6831-4e1a-bb17-a001fbe20948
Copyright ©
© 2013
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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