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      Mitochondrial dynamics and inheritance during cell division, development and disease.

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          Abstract

          During cell division, it is critical to properly partition functional sets of organelles to each daughter cell. The partitioning of mitochondria shares some common features with that of other organelles, particularly in the use of interactions with cytoskeletal elements to facilitate delivery to the daughter cells. However, mitochondria have unique features - including their own genome and a maternal mode of germline transmission - that place additional demands on this process. Consequently, mechanisms have evolved to regulate mitochondrial segregation during cell division, oogenesis, fertilization and tissue development, as well as to ensure the integrity of these organelles and their DNA, including fusion-fission dynamics, organelle transport, mitophagy and genetic selection of functional genomes. Defects in these processes can lead to cell and tissue pathologies.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0080
          1471-0072
          Oct 2014
          : 15
          : 10
          Affiliations
          [1 ] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
          [2 ] 1] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA. [2] Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.
          Article
          nrm3877 NIHMS644044
          10.1038/nrm3877
          4250044
          25237825
          62dac43b-067a-4d6d-9e31-3bb76a9a85c1
          History

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