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      Therapeutic novelties of inhaled corticosteroids and bronchodilators in asthma.

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          Abstract

          Orally inhaled agents are a key therapeutic class for treatment of asthma. Inhaled corticosteroids (ICS) are the most effective anti-inflammatory treatment for asthma thus representing the first-line therapy and bronchodilators complement the effects of ICSs. A significant body of evidence indicates that addition of a β2-agonist to ICS therapy is more effective than increasing the dose of ICS monotherapy. In this paper, pharmacological features of available ICSs and bronchodilators will be reviewed with a focus on fluticasone propionate/formoterol fumarate combination which represents the one of the most powerful ICS acting together with the most rapid active LABA.

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          Author and article information

          Affiliations
          [1 ] Department of Clinical and Biological Sciences, University of Torino, Torino, Italy. Electronic address: fabioluigimassimo.ricciardolo@unito.it.
          [2 ] Department of Pathophysiology and Transplantation, University of Milano, IRCCS Fondazione Cà Granda, Milano, Italy.
          [3 ] Respiratory Unit, San Paolo Hospital, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy.
          [4 ] Unit of Respiratory Clinical Pharmacology, Department of System Medicine, University of Rome Tor Vergata, Roma, Italy.
          Journal
          Pulm Pharmacol Ther
          Pulmonary pharmacology & therapeutics
          Elsevier BV
          1522-9629
          1094-5539
          Aug 2015
          : 33
          26014510 S1094-5539(15)00051-6 10.1016/j.pupt.2015.05.006

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