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      Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India

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          Abstract

          Background

          Co-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, however concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented. An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occurred in and around Delhi in 2006. This is the first report from India with high percentage of concurrent infections with different dengue virus serotypes circulating during one outbreak.

          Results

          Acute phase sera from patients were tested for the presence of dengue virus RNA by RT-PCR assay. Of the 69 samples tested for dengue virus RNA, 48 (69.5%) were found to be positive. All the four dengue virus serotypes were found to be co-circulating in this outbreak with DENV-3 being the predominant serotype. In addition in 9 of 48 (19%) dengue virus positive samples, concurrent infection with more than one dengue virus serotype were identified.

          Conclusion

          This is the first report in which concurrent infections with different dengue virus serotypes is being reported during an outbreak from India. Delhi is now truly hyperendemic for dengue.

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          Research on dengue during World War II.

          A SABIN (1952)
          Article 0 comments Cited 210 times – based on 0 reviews     Review now
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            The changing epidemiology of dengue in Delhi, India

            Ekta Gupta, Lalit Dar, Geetanjali Kapoor … (2006)
            Background A major DHF outbreak occurred in Delhi in 1996. Following this another outbreak was reported in the year 2003. In the years 2004 and 2005, though no outbreak was reported, a definitely higher number of samples were received in the virology laboratory of A.I.I.M.S. from suspected cases of dengue infection. This study was designed to compare the serological and virological profiles of confirmed dengue cases in the years 2003, 2004 and 2005. Results Out of 1820 serum samples received from suspected cases in all three years, 811 (44.56%) were confirmed as dengue infection serologically. Out of these confirmed dengue cases maximum cases, in all three years, were seen in the age group 21–30 years. There was an increase in the number of samples received in the post monsoon period (September to November) with a peak in the second and third week of October. More samples were received from DHF cases in the year 2005 than 2004 and 2003. All four dengue serotypes were seen co-circulating in the year 2003, followed by complete predominance of dengue serotype 3 in 2005. Conclusion Epidemiology of dengue is changing rapidly in Delhi. Dengue infections are seen every year thus making it an endemic disease. After co-circulation of all serotypes in 2003, now dengue serotype 3 is emerging as the predominant serotype.
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              Common occurrence of concurrent infections by multiple dengue virus serotypes.

              A Vorndam, Richard M Pino, María E. Rosado … (1999)
              The co-circulation of all 4 dengue virus serotypes in the same community, common since the 1950s in Southeast Asia, has now become a frequent occurrence in many Caribbean Islands, Mexico, and Central and South America in the past 20 years. As a consequence, the frequency of concurrent infections would be expected to increase in these areas. To assess this, using state of the art technology, we screened viremic serum samples and mosquitoes inoculated with serum samples collected during epidemics involving multiple dengue virus serotypes in Indonesia, Mexico, and Puerto Rico for virus isolation. Of 292 samples tested, 16 (5.5%) were found to contain 2 or more dengue viruses by an indirect immunofluorescence test and/or the reverse transcriptase-polymerase chain reaction.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Virol J
                Title: Virology Journal
                Publisher: BioMed Central
                ISSN (Electronic): 1743-422X
                Publication date Collection: 2008
                Publication date (Electronic): 9 January 2008
                Volume: 5
                Page: 1
                Affiliations
                [1 ]Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
                [2 ]Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
                [3 ]Department of Pediatrics All India Institute of Medical Sciences, New Delhi, India
                Article
                Publisher ID: 1743-422X-5-1
                DOI: 10.1186/1743-422X-5-1
                PMC ID: 2253528
                PubMed ID: 18182120
                SO-VID: 62e887c3-7e4b-46e9-96d5-96ff7f72259b
                Copyright © Copyright © 2008 Bharaj et al; licensee BioMed Central Ltd.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 23 July 2007
                Date accepted : 9 January 2008
                Categories
                Subject: Research

                ScienceOpen disciplines: Microbiology & Virology
                Data availability:
                ScienceOpen disciplines: Microbiology & Virology

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