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      Effect of Beta-Adrenergic Blockade by Propranolol upon Intravascular Coagulation in the Rat Kidney

      ,

      Nephron

      S. Karger AG

      Acute renal failure, Intravascular coagulation, Fibrin, Renal function, Beta-blockade, Propranolol

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          Abstract

          Disseminated intravascular coagulation in rats was induced by intravenous infusion of thrombin for 30 min. The glomerular filtration rate was measured as the clearance of polyethylene glycol 1000. The fibrin deposition in organs was quantitated by a method using previous injection of <sup>125</sup>I-labelled fibrinogen. Administration of the β-adrenergic blocking agent, propranolol, prevented the decrease in glomerular filtration rate after infusion of thrombin. This result could be explained by an observed partial redistribution of the fibrin from the kidneys to the lungs.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1979
          1979
          02 December 2008
          : 24
          : 5
          : 246-249
          Affiliations
          State Institute of Forensic Medicine, Clinical Research Center and Department of Pathology I, University of Linköping, Linköping
          Article
          181725 Nephron 1979;24:246–249
          10.1159/000181725
          503267
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

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