Effect of Beta-Adrenergic Blockade by Propranolol upon Intravascular Coagulation in the Rat Kidney

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Abstract

Disseminated intravascular coagulation in rats was induced by intravenous infusion of thrombin for 30 min. The glomerular filtration rate was measured as the clearance of polyethylene glycol 1000. The fibrin deposition in organs was quantitated by a method using previous injection of <sup>125</sup>I-labelled fibrinogen. Administration of the β-adrenergic blocking agent, propranolol, prevented the decrease in glomerular filtration rate after infusion of thrombin. This result could be explained by an observed partial redistribution of the fibrin from the kidneys to the lungs.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1979

Publication date (Print): 1979

Publication date (Electronic): 02 December 2008

Volume: 24

Issue: 5

Pages: 246-249

Affiliations

State Institute of Forensic Medicine, Clinical Research Center and Department of Pathology I, University of Linköping, Linköping

Article

Publisher ID: 181725 Other ID: Nephron 1979;24:246–249

DOI: 10.1159/000181725

PubMed ID: 503267

SO-VID: 6313fdf1-1678-45ea-b482-ece2f630a52a

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 06 February 1979

Page count

Pages: 4

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