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      The effects of tolterodine on anterior segment and choroidal thickness in patients with overactive bladder syndrome

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          Abstract

          Background:

          To evaluate the effects of tolterodine on anterior segment and choroidal thickness by using the Pentacam system and optical coherence tomography (OCT) (Pentacam).

          Methods:

          A total of 122 eyes of 61 patients (34 female; 27 male) were included in the study. All patients underwent a regular ocular examination and intraocular pressure measurements before and after 3 months of antimuscarinic drug tolterodine treatment, in addition, pupil diameter, anterior chamber depth, anterior chamber volume, anterior chamber angle, and lens thickness were measured through Pentacam (Oculus Inc., Wetzlar, Germany) system. Measurements of choroidal thickness were performed by OCT (Spectralis ®, Heidelberg Engineering, Heidelberg, Germany).

          Results:

          The mean age was 58.4 ± 7.3 years and 56.5 ± 11.1 years for female and male patients. The mean intraocular pressure was 15.10 ± 2.75 mmHg before treatment and 15.18 ± 2.65 mmHg after treatment. Pupil diameters were 3.09 ± 0.48 mm before treatment and 3.12 ± 0.43 mm after treatment. Anterior chamber depth, before and after treatment were 2.68 ± 0.65 mm and 2.70 ± 0.61 mm. The mean value for subfoveal choroidal thickness was 267.92 ± 81.35 μm before the administration of tolterodine, whereas the mean choroidal thickness was 271.83 ± 75.42 μm after the administration of tolterodine. The alterations in the subfoveal choroidal thickness were not statistically significant ( p = 0.862).

          Conclusions:

          After 3 months of therapy with tolterodine, there were no significant changes in anterior segment parameters and choroidal thickness.

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          Author and article information

          Contributors
          Journal
          Ther Adv Urol
          Ther Adv Urol
          TAU
          sptau
          Therapeutic Advances in Urology
          SAGE Publications (Sage UK: London, England )
          1756-2872
          1756-2880
          11 April 2017
          October 2017
          : 9
          : 5
          : 91-97
          Affiliations
          [1-1756287217701861]Department of Ophthalmology Clinic, Ankara Training and Research Hospital, Ankara, Turkey
          [2-1756287217701861]Department of Urology Clinic of Ankara Training and Research Hospital, Sukriye Mahallesi, Ulucanlar Caddesi, No:89, 06340, Ankara, Turkey
          [3-1756287217701861]Department of Ophthalmology Clinic, Ankara Training and Research Hospital, Ankara, Turkey
          [4-1756287217701861]Department of Ophthalmology Clinic, Ankara Training and Research Hospital, Ankara, Turkey
          [5-1756287217701861]Department of Ophthalmology Clinic, Ankara Training and Research Hospital, Ankara, Turkey
          [6-1756287217701861]Department of Urology Clinic, Ankara Training and Research Hospital, Ankara, Turkey
          Author notes
          Article
          PMC5444624 PMC5444624 5444624 10.1177_1756287217701861
          10.1177/1756287217701861
          5444624
          28588646
          631fd275-aebc-4db6-9b85-5d1c80054685
          © The Author(s), 2017
          History
          : 22 December 2016
          : 7 March 2017
          Categories
          Original Research

          tolterodine,pentacam,OCT,choroidal thickness,anterior segment

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